PhD Scientific Days 2017

Poster Presentation: Clinical Sciences

P20: Diminished sensory nerve function among patients with high risk for the development of type 2 diabetes mellitus screened by the FINDRISC questionnaire

Előadó neve

Dr. Vági, Orsolya

Előadó munkahelye

1st Department of Internal Medicine, Semmelweis University, Budapest

Előadó telefonszáma

+36-30-470-96-91

Előadó e-mail címe

vagiorsi@gmail.com

Az előadás címe

Diminished sensory nerve function among patients with high risk for the development of type 2 diabetes mellitus screened by the FINDRISC questionnaire

Szerző(k) neve és munkahelye

O Vági E 1 , AE Körei 1, Z Putz 1, I Istenes1 , N Hajdú1, MSKepler 2, P Torzsa 3, Kepler P 1
1 1st Department of Internal Medicine, Semmelweis University, Budapest
2 3rd Department of Internal Medicine, Semmelweis University, Budapest
3 Department of Family Medicine, Semmelweis University, Budapest

Szekció

Poster Presentation: Clinical Sciences

Data of the presenter

Doctoral School: Basic Medicine
Program: The Mechanisms of Normal and Pathologic Functions of the Circulatory System
Supervisor: Péter Kempler
e-mail: vagiorsi@gmail.com

Text of the abstract

Diabetes mellitus and even impaired glucose tolerance are associated with sensory nerve disfunction. The Finnish Diabetes Risk Score (FINDRISC) is a validated and one of the most widely used T2DM risk score questionnaire.
The aim of our study was to compare sensory nerve function among patients with higher future T2DM risk (minimum 12 points in the FINDRISC questionnaire) with healthy conrol subjects.
Our study involved 22 patients with higher future T2DM risk (mean age: 55,4 ±15, female 8, fasting glucose 5,6±0,4 mmol/l, FINDRISC total score 18[14;19]) and 13 healthy controls (mean age:56,6±11 , female 5, fasting glucose 4,9±0,5 mmol/l, FINDRISC total score 8[6;9]). Sensory function was evaluated by Neurometer (Neurotron Inc., Baltimore, USA) device, 128 Hz calibrated tuning fork, Semmes-Weinstein monofilament and Q-sense (Medoc Ltd., Yamat Rishai, Israel) device. Neuropathic symptoms was measured by NTSS-6 (Neuropathy Total Symptom Score) questionnaire.
Patients with higher future T2DM risk had significantly higher vibration perception thresholds both on the upper extremities (6,4 vs 7,7 , p=0,002) and both on the lower extremities (5,7 vs 7,5, p=0,006) than controls . In case of stimulating the median nerve at 250 Hz the current perception thresholds were significantly higher among patients with higher future T2DM risk compared to controls (1,28 mA vs 0,92 mA, p=0,03). Moreover, patients with higher future T2DM risk had significantly higher heat perception thresholds than healthy control subjects (40,9 oC vs 37,4 oC, p= 0,049). In the case of testing of protective sensory function using a monofilament there wasn’t any difference between the two groups (p=0,348), we had not identify any case of neuropatic syndrome.
Diminished sensory nerve function might be present among patients with high risk for the development of type 2 diabetes mellitus screened by the FINDRISC questionnaire, compared to healthy controls. Our results highlight the importance of early neuropathy assessment.

Azonosító

P20

Kind

Szabad

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1019

Authors (legacy)

O Vági E 1 , AE Körei 1, Z Putz 1, I Istenes1 , N Hajdú1, MSKepler 2, P Torzsa 3, Kepler P 1
1 1st Department of Internal Medicine, Semmelweis University, Budapest
2 3rd Department of Internal Medicine, Semmelweis University, Budapest
3 Department of Family Medicine, Semmelweis University, Budapest