PhD Scientific Days

Poster Presentation: Cardiovascular

P65: Distinguishing arrhythmogenic right ventricular cardiomyopathy (ARVC) from athlete’s heart using cardiac magnetic resonance imaging (CMR)

Előadó neve

Dr. Czimbalmos, Csilla

Előadó munkahelye

Heart and Vascular Center, Semmelweis University

Előadó telefonszáma

+36206632858

Előadó e-mail címe

csilla.czimbalmos@gmail.com

Az előadás címe

Distinguishing arrhythmogenic right ventricular cardiomyopathy (ARVC) from athlete’s heart using cardiac magnetic resonance imaging (CMR)

Szerző(k) neve és munkahelye

Csilla Czimbalmos1, Hajnalka Vágó1, Ibolya Csécs1, Attila Tóth1, Ferenc Suhai1, Bea Horváth1, Zsófia Dohy1, Tamás Simor2, Dávid Becker1, Béla Merkely1
1 Heart and Vascular Center, Semmelweis University, Budapest
2 Heart Institute, Faculty of Medicine, University of Pécs , Pécs

Szekció

Poster Presentation: Cardiovascular

Data of the presenter

Doctoral School: Basic Medicine
Program: Cardiovascular Disorders: Physiology and Medicine of Ischaemic Circulatory Diseases
Supervisor: Béla Merkely
Email address: csilla.czimbalmos@gmail.com

Text of the abstract

ARVC is a major cause of life-threatening arrhythmias in young athletes. However in highly trained athletes the diagnosis is complicated because of overlapping features such as elevated right ventricular end-diastolic volume index (RVEDVi).
Our goal was to determine CMR parameters and gender-specific cut-off values which can help to differentiate ARVC from athlete’s heart.
Between 2010 and 2015 CMR examination was performed on 480 patients due to the suspicion of ARVC. In 45 patients (38±10y,30 male) ECG abnormalities, arrhythmias, family history, histology and/or CMR parameters fulfilled revised TFC. Additionally 80 professional athletes free of complaint (26±4y,50 male) were examined by CMR. RVEDVi, right ventricular ejection fraction (RVEF) and the calculated derived parameters (LVEDV/RVEDV and LVEF/RVEF) were compared. Area under the ROC curves (AUC) of these CMR parameters were analysed, and optimal gender specific cut-off values were established from ROC curves with the highest optimal sensitivity and specificity.
There was no significant difference between RVEDVi of ARVC patients and athletes in both males and females. RVEF was significantly lower in ARVC patients compared to athletes. LVEDV/RVEDV and LVEF/RVEF of both male and female patients showed significant difference compared to the athlete's group (p<0.01).
In both gender, AUC of RVEF, LVEF/RVEF and LVEDV/RVEDV shows that these parameters can help to distinguish ARVC and athletes heart (p<0.01), but RVEDVi can not (p=NS).
Male cut-off value for ratio of RVEF less than 48.2%, LV/RVEF more than 1.145 discriminated between athlete’s heart and ARVC with a sensitivity of 53% and a specificity of 100%.
In 6 athletes (28±4y,5 male) ARVC was diagnosed based on CMR, ECG, arrhythmias and family history. RVEF, LV/RVEF and LV/RVEDV were in the pathological range in 3, 6 and 5 cases, respectively.
In highly trained healthy athletes RVEDVi is in the range of major TFC, while RVEF, LV/RVEDV and LV/RVEF could be useful parameters in differential diagnosis.

Azonosító

P65

Kind

Szabad

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1021

PhD Scientific Days 2017

Budapest, 11-12 April 2017