PhD Scientific Days 2017

Oral Presentations: Mental Health

Increased fMRI BOLD signal response of anterior cingulate cortex during serotoninergic challenge in migraine

Előadó neve

Édes, Andrea

Előadó munkahelye

MTA-SE-NAP B Genetic Brain Imaging Migraine Research Group

Előadó telefonszáma

06307301011

Előadó e-mail címe

edes.andrea88@gmail.com

Az előadás címe

Increased fMRI BOLD signal response of anterior cingulate cortex during serotoninergic challenge in migraine

Szerző(k) neve és munkahelye

Andrea Edit Edes 1,2, Shane McKie 3, Terezia Zsombok 1,2, Daniel Baksa1,2, Gyorgy Bagdy 2,4,5, Gabriella Juhasz 1,2,3,4,5
1 MTA-SE-NAP B Genetic Brain Imaging Migraine Research Group, Budapest, Hungary
2 Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary
3 Neuroscience and Psychiatry Unit, The University of Manchester, UK and Manchester Academic Health Sciences Centre
4 MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Budapest, Hungary
5 NAP-A-SE New Antidepressant Target Research Group, Budapest, Hungary

Szekció

Oral Presentations: Mental Health

Data of the presenter

Doctoral school: Doctoral School of Mental Health Sciences
Program: Psychiatry
Supervisor: Dr. Gabriella Juhász
e-mail address: edes.andrea88@gmail.com
Oral presentation

Text of the abstract

Functional and structural imaging of migraine revealed alterations of the pain-modulating system, including the anterior cingulate cortex (ACC) which has an important role in top-down control of subcortical areas. The increased activation of ACC has been observed in healthy subjects during serotoninergic challenge. However, it has been unknown so far whether serotonergic control of ACC activation is altered in migraine.

In this study we investigated how serotoninergic challenge influences activation pattern of ACC in migraine patients compared to controls.

Changes in brain activation following 7.5 mg i.v. citalopram infusion, were measured in 27 healthy and 6 migraine volunteers using within-subject, placebo-controlled, double-blind, randomized design. The volunteers took part a 30 minutes-long challenge pharmacological fMRI (phMRI) two times, placebo and citalopram respectively. These occasions were separated by at least two weeks. The phMRI images were acquired at a 3T MRI scanner (Philips Achieva) using a T2*-weighted echo-planar sequence. Imaging data were analysed using SPM 12 for MATLAB.

The changes in ACC activation over time during and after citalopram infusion were obtained by time x drug interaction F-test (primary uncorrected p=0.001 with secondary Family Wise Error corrected p=0.05). Migraineurs showed significantly different ACC activation compared to controls. Two clusters were observed in the right ACC (p(FWE)=0.006, 9 voxels and p(FWE)=0.022, 6 voxels) where the extracted time-series indicated that activation of ACC in migraine patients was significantly higher in the first 8 minutes of infusion than in healthy controls.

These results clearly demonstrate that migraineurs are more sensitive to alterations of serotoninergic tone, since they have increased ACC activation compared to the control group especially in the first few minutes of drug response. The altered response to citalopram in migraine patients may be the result of imbalance between ACC and other pain modulating areas that may contribute to repeated migraine attacks.

Kind

Szabad

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1043

Authors (legacy)

Andrea Edit Edes 1,2, Shane McKie 3, Terezia Zsombok 1,2, Daniel Baksa1,2, Gyorgy Bagdy 2,4,5, Gabriella Juhasz 1,2,3,4,5
1 MTA-SE-NAP B Genetic Brain Imaging Migraine Research Group, Budapest, Hungary
2 Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary
3 Neuroscience and Psychiatry Unit, The University of Manchester, UK and Manchester Academic Health Sciences Centre
4 MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Budapest, Hungary
5 NAP-A-SE New Antidepressant Target Research Group, Budapest, Hungary