PhD Scientific Days 2017

Oral Presentations: Cardiovascular

Serum uric acid level is independently associated with subclinical atherosclerosis in asymptomatic population

Előadó neve

Dr. Kiss, Loretta

Előadó munkahelye

Semmelweis University, Heart and Vascular Center

Előadó telefonszáma

06303990011

Előadó e-mail címe

kisslotti@gmail.com

Az előadás címe

Serum uric acid level is independently associated with subclinical atherosclerosis in asymptomatic population

Szerző(k) neve és munkahelye

Loretta Kiss1, Zsolt Bagyura1, Réka Vadas1, Árpád Lux1, Lívia Polgár1, Pál Soós1, Zsolt Szelid1, Dávid Becker1, Béla Merkely1
Semmelweis University, Heart and Vascular Center, Budapest

Szekció

Oral Presentations: Cardiovascular

Data of the presenter

Doctoral School: Basic Medicine
Program: Cardiovascular Disorders: Physiology and Medicine of Ischaemic Circulatory Diseases
Supervisor: Dávid Becker, Zsolt Szelid
E-mail address of presenter: kisslotti@gmail.com
It is preferred to be presented as an oral presentation.

Text of the abstract

Introduction: Searching for early atherosclerosis at subclinical stages is an important step of cardiovascular prevention. Carotid ultrasound and heart CT scan are sensitive non-invasive tools for detecting subclinical atherosclerosis. Higher serum uric acid levels are known to be associated with cardiovascular diseases. However, there is some inconsistence regarding the information on the independence of the association.
Aim: The aim of our study was to assess the prevalence of subclinical atherosclerosis and its associations with SUA and conventional risk factors in an asymptomatic population. Methods: A voluntary cardiovascular screening program was performed with 2420 participants. Participants with a history of cardiovascular disease were excluded from further analysis. Parts of the screening were health questionnaire, physical examination, carotid ultrasound, laboratory tests and CT scan as a sub-study.
Results: Mean CIMT max was 0.75 ±0.14 mm. CIMT max was above 0.9 mm in 270 cases (17.9%). A Total Agatston score of 0 was found in 33.1%. The score was above 300 in 15.5%. Median score was 17,8 (136). SUA showed positive correlation with both CIMT (0.289, p <0.01) and total Ca-score (0.257, p<0.01). Logistic regression analysis adjusted for conventional risk factors revealed that SUA level is independent predisposing factor for both CIMT max>0.9 (OR: 1.002, p<0.001) and total Ca-score>300 (OR: 1.01, p<0.001).
Conclusion: In our study, association of SUA with subclinical atherosclerosis was still present after the effects of conventional risk factors were eliminated.

Kind

Szabad

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1101

Authors (legacy)

Loretta Kiss1, Zsolt Bagyura1, Réka Vadas1, Árpád Lux1, Lívia Polgár1, Pál Soós1, Zsolt Szelid1, Dávid Becker1, Béla Merkely1
Semmelweis University, Heart and Vascular Center, Budapest