PhD Scientific Days 2017

Oral Presentations: Pharmaceutical

Possibilities of anti-drug vaccine design

Előadó neve

Dr. Köteles, István

Előadó munkahelye

Semmelweis Egyetem, Gyógyszerésztudományi Kar, Gyógyszerészi Kémiai Intézet

Előadó telefonszáma

+36302336558

Előadó e-mail címe

koteles.istvan@pharma.semmelweis-univ.hu

Az előadás címe

Possibilities of anti-drug vaccine design

Szerző(k) neve és munkahelye

István Köteles
Semmelweis Egyetem, Gyógyszerésztudományi Kar, Gyógyszerészi Kémiai Intézet, Budapest

Szekció

Oral Presentations: Pharmaceutical

Data of the presenter

Pharmaceutical Sciences
Modern Trends in Pharmaceutical Scientific Research
Sándor Hosztafi
koteles.istvan@pharma.semmelweis-univ.hu

Text of the abstract

Drugs of abuse are small molecules that typically do not induce an antibody response following injection or inhalation. To induce antibodies against small molecules, structural surrogates of the molecules, which were named “haptens”, must be coupled to immunogenic proteins, called “carriers”. These structural surrogates are typically drug-linker adducts, in which the linker has a terminal functional group that forms a covalent bond with the carrier. The efficacy of these conjugate vaccines depends on several factors including hapten design, coupling strategy, hapten density, carrier protein selection, and vaccine adjuvant.

Our aim was to synthesize haptens of morphine and its derivatives. For this purpose we used the nor-molecules in addition reactions. These products are hapten precursors and they can be converted into the desired molecules, containing carboxyl or amine functional groups. After this step it is possible to couple them to amino acids or proteins.

As a result we developed three ways to obtain morphine derivative haptens. We synthesized over 40 previously unknown molecules. Their structures were confirmed with NMR and MS spectroscopy and the purity was checked with TLC.

At present there are several ongoing researches in this topic worldwide to obtain an effective vaccine against heroin, cocaine and nicotine. This fact gives grounds for our research as well.

Kind

Szabad

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1155

Authors (legacy)

István Köteles
Semmelweis Egyetem, Gyógyszerésztudományi Kar, Gyógyszerészi Kémiai Intézet, Budapest