PhD Scientific Days

Poster Presentation: Clinical Sciences

P23: Association between intra pancreatic lipid content and HbA1c levels in middle aged Hungarian women with a history of gestational diabetes mellitus.

Előadó neve

Kasiri, Elnaz

Előadó munkahelye

2nd Department of Internal Medicine , Clinical Doctoral School, Semmelweis University , Budapest,Hungary

Előadó telefonszáma

06303276747

Előadó e-mail címe

Elnaz.kasiri@med.semmelweis-univ.hu

Az előadás címe

Association between intra pancreatic lipid content and HbA1c levels in middle aged Hungarian women with a history of gestational diabetes mellitus.

Szerző(k) neve és munkahelye

Elnaz Kasiri 1 , Viktor Gál 2 , Ákos Nádasdi 1 , Klara Rosta 3, Anikó Somogyi 1, Gábor Firneisz 1,4
1 2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
2 BIC unit of RCNS of the Hungarian Academy of Sciences (HAS ).
3 Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria, 1st Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
4 Hungarian Academy of Sciences - Semmelweis University, Molecular Medicine Research Group, Budapest, Hungary.

Szekció

Poster Presentation: Clinical Sciences

Data of the presenter

Doctoral School: Clinical Medicine
Program: Examination of etiopatological and genetic factors of diabetes mellitus and liver diseases and their complications .
Supervisor:Gábor Firneisz
Email: elnaz.kasiri@med.semmelweis-univ.hu

Text of the abstract

Introduction: The intra pancreatic lipid content (IPLC) and β-cell dysfunction was recently reported to contribute to type 2 diabetes mellitus (T2DM) development and individuals with prior gestational diabetes mellitus (‘pGDM’) have a higher risk for T2DM development later in life.
Aim: To investigate the potential association among IPLC, MTNR1B rs10830963 genotype, fasting and post challenge plasma glucose values; additional clinical data including BMI, waist to hip ratio, HbA1c in young-middle aged population with pGDM and in controls.
Methods: We obtained data from 26 participants (mean age: 36.7±4.17) of which 15 subjects were with pGDM and 11 were controls with negative history of GDM. 75g OGTT (0’, 30’ and 120’) was performed. The clinical and biochemical characteristics were analyzed with Statistica program (vs13.2), the Mann-Whitney U test and Spearman’s Rank order correlation test (SRO) were used. IPLC was measured by proton magnetic resonance spectroscopy and chemical shift imaging technique. Allele specific PCR (KASP, LGC Genomics) was used for MTNR1B rs10830963 genotyping.
Results: Six individuals (pGDM/CTRL: 4/2) were diagnosed with impaired glucose tolerance at OGTT. Fourteen individuals had BMI > 25 kg/m2 and 12 had BMI < 25 kg/m2. Individuals with BMI over 25 kg/m2 had significantly greater pancreatic IPLC compared with normal BMI subjects (MWU p=0.04) (Mean= 8.55± 0.03 % and 5,93±2.61 % respectively). Additionally HbA1c was positively correlated with IPLC significantly (p=0.009; r=0.52) in the whole study population. This correlation was especially significant in pGDM subgroup p=0.0075; r=0.65) but not within the control group. No further correlations were found.
Conclusion: Current study suggested that IPLC might be associated with higher HbA1c levels even in the non-diabetic young middle aged population with a history of GDM. More data is needed to confirm that this association might be an early feature of progressive metabolic disorder that may lead to T2DM development decades later.

Azonosító

P23

Kind

Szabad

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1163

PhD Scientific Days 2017

Budapest, 11-12 April 2017