PhD Scientific Days 2017

Oral Presentations: Cardiovascular

Evaluation of coronary plaque progression using coronary CT angiography

Előadó neve

Szilveszter, Bálint

Előadó munkahelye

Semmelweis University, Heart and Vascular Center, MTA-SE Cardiovascular Imaging Research Group

Előadó telefonszáma

0036206663857

Előadó e-mail címe

szilveszter.balint@gmail.com

Az előadás címe

Evaluation of coronary plaque progression using coronary CT angiography

Szerző(k) neve és munkahelye

Bálint Szilveszter , Borbála Vattay
Semmelweis University, Heart and Vascular Center, MTA-SE Cardiovascular Imaging Research Group

Szekció

Oral Presentations: Cardiovascular

Data of the presenter

Doctoral School Basic Medicine (I/1)
01. Cardiovascular Disorders: Physiology and Medicine of Ischaemic Circulatory Diseases
Supervisor: Pál Maurovich-Horvat
szilveszter.balint@gmail.com

Text of the abstract

Introduction:
State-of-the art coronary CT angiography (CTA) provides robust and nonivasive assessment of coronary artery disease. Prior studies have demonstrated the prognostic value of high-risk plaque features and plaque burden for adverse events. Coronary atheroclerosis is a dynamic and progressive process therefore the evaluation of changes in plaque components and stenosis severity could improve individual risk prediction.
Aims:
We aimed to evaluate the characteristics of coronary plaque progression using serial CTA images.
Methods:
In our retrospective study we enrolled patients who underwent serial coronary CTA with at least 1 year difference between the two examination. In each patient, segment involvement score (SIS) was used to quantify the number of segments with any plaque, whereas segment stenosis score (SSS) was calculated by summing the stenosis scores of each segment. High-risk plaque features were also evaluated by a single reader. Coronary plaque progression was defined as more than 1 point increase in SSS or the appearance of a new high-risk plaque.
Results:
We enrolled 66 patients in our study (mean age 58,5 ± 9,3 years, females 28.8%). In average, 3.1 ± 1.4 years has passed between the two scans. In total, 275 plaques were detected on the baseline images vs 320 plaques on follow-up (p<0.0001). SSS and SIS was significantly higher on the follow-up scans: SSS 5.9 ± 4.5 vs. 7.9 ± 6.8 (p<0.001), SIS 4.1 ± 2.7 vs. 4.8 ± 3.1 (p<0.001). 57.6% of the patients had any plaque progression.
Conclusion:
We detected significant progression of coronary atherosclerosis using serial CTA images that might be associated with poor clinical outcomes. With the help of coronary CTA we can monitor morphological changes in plaque composition.

Kind

Szabad

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1179

Authors (legacy)

Bálint Szilveszter , Borbála Vattay
Semmelweis University, Heart and Vascular Center, MTA-SE Cardiovascular Imaging Research Group