PhD Scientific Days 2017

Oral Presentations: Neurosciences

Sex differences in sleep spindle lateralization

Előadó neve

Dr. Ujma, Péter

Előadó munkahelye

Semmelweis University, Institute of Behavioural Sciences

Előadó telefonszáma

+36303519250

Előadó e-mail címe

peteru88@gmail.com

Az előadás címe

Sex differences in sleep spindle lateralization

Szerző(k) neve és munkahelye

Péter P. Ujma 1, Róbert Bódizs 1, Martin Dresler 2
1 Semmelweis University, Institute of Behavioural Sciences, Budapest, Hungary
2 Max Planck Institute of Psychiatry, Munich, Germany

Szekció

Oral Presentations: Neurosciences

Data of the presenter

Postdoctor, New National Excellence Award (ÚNKP) winner (an invitation via email was received)
E-mail address: peteru88@gmail.com

This work was supported by the ÚNKP-16-4 New National Excellence Program of the Ministry of Human Capacities.

Text of the abstract

Introduction. Sleep spindles are thalamocortical oscillations in NREM sleep which play an important role in cognitive abilities and information processing. Sleep spindles, cognitive abilities and functional lateralization are all known to exhibit sex differences.
Aims. The goal of this study was to determine how sleep spindle lateralization is affected by sex.
Method. We used all-night scalp EEG data for all analyses. In study 1, we calculated individual sleep spindle parameters (density, duration and amplitude for both slow and fast spindles) for 251 subjects (age 4-69 years, 122 females) and compared individual spindle parameter lateralization indices. In study 2, we calculated the Weighted Phase Lag Index, a measure of signal synchronization, between a set of electrode pairs in 159 adult and 29 child subjects.
Results. Our results indicate that sleep spindle activity is asymmetrically distributed over the scalp, and its laterality changes as a function of both age and sex. Most spindle measures are symmetrical or left-lateralized, with the exception of prefrontal spindle amplitude. The left lateralization of fast spindle density and duration increases with age in males, but not females. In females, occipital fast spindles exhibit greater left hemispheric dominance than in males. Inter-channel EEG connectivity in NREM sleep in the sleep spindle frequency range is substantially greater in adult females. The difference is greatest in centrotemporal derivation pairs. In adult males, inter-channel EEG connectivity is greater in the beta range in both REM and NREM sleep, also mainly in centrotemporal derivation pairs. No sex difference is seen in the connectivity of children.
Conclusion. Sleep spindle activity is highly lateralized, possibly reflecting the lateralization of cognitive functions. Changing laterality patterns with age and sex may indicate a non-uniform vulnerability to loss of cognitive functions after brain damage.

Kind

Szabad

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1181

Authors (legacy)

Péter P. Ujma 1, Róbert Bódizs 1, Martin Dresler 2
1 Semmelweis University, Institute of Behavioural Sciences, Budapest, Hungary
2 Max Planck Institute of Psychiatry, Munich, Germany