PhD Scientific Days 2017

Poster Presentation: Pharmaceutical

P03: Tracking of the optimum composition of hydroxypropyl cellulose-polyvinyl alcohol aqueous solutions containing papaverine hydrochloride for fiber formation

Előadó neve

Dr. Kazsoki, Adrienn

Előadó munkahelye

University Pharmacy Department of Pharmacy Administration, Semmelweis University

Előadó telefonszáma

06302060093

Előadó e-mail címe

kazsoki.adrienn@pharma.semmelweis-univ.hu

Az előadás címe

Tracking of the optimum composition of hydroxypropyl cellulose-polyvinyl alcohol aqueous solutions containing papaverine hydrochloride for fiber formation

Szerző(k) neve és munkahelye

Adrienn Kazsoki1, Péter Szabó1, Barnabás Palcsó1, Károly Süvegh2, Romána Zelkó1
1 University Pharmacy Department of Pharmacy Administration, Semmelweis University, Budapest
2 Laboratory of Nuclear Chemistry, Eötvös Loránd University, Budapest

Szekció

Poster Presentation: Pharmaceutical

Data of the presenter

Doctoral School: Pharmaceutical Sciences
Program: Modern Trends in Pharmaceutical Scientific Research
Supervisor: Romána Zelkó
E-mail: kazsoki.adrienn@pharma.semmelweis-univ.hu

Text of the abstract

The opium alkaloid papaverine hydrochloride has a non-specific direct relaxant effect on smooth muscles. Orally administered papaverine has been shown to increase regional cerebral blood flow, but some unfavorable properties, such as slight water solubility, poor peroral bioavailability associated with high intra- and inter-individual variability, and the risk of potential liver damage confine its clinical applicability. A nanofibrous buccal formulation can improve the oral bioavailability of the drug with the enhanced solubility and lack of the first pass metabolism. The intra-and inter-individual variability can also be decreased as well.
The aim of this study was to prepare papaverine hydrochloride loaded buccal nanofibrous sheets and to determine the optimum composition of hydroxypropyl cellulose (HPC) - poly(vinyl alcohol) (PVA) aqueous solutions for electrospun fiber formation with the combination of rheological, molar reflectance, ortho-Positronium (o-Ps) lifetime and scanning electron microscopy measurements.
In the course of the electrospinning process, water soluble HPC and PVA were chosen as mucoadhesive polymers. The total polymer concentration was kept constant at 15 % (w/w) and only the ratio of the two polymers was changed according to the predetermined proportions.
Correlation was found between the micro- and macrostructural properties of the polymer solutions and their electrospinnability. Along with the changes of the polymer ratio, the corresponding morphology of the electrospun samples also varied. Decreasing the HPC ratio of gels resulted in a transition from the spray-dried film-like structure through fibrous film to fibers. Polymer solutions of the lowest elasticity and slightest intermolecular interactions and the more ordered intramolecular structure indicated by the lowest ortho-positronium lifetimes contributed to the best fiber characteristics of the samples.
The results demonstrate that the combination of micro- and macrostructural characterization of the gels and the electrospun samples is an effective way to fine-tailor the formulation in order to achieve the optimum functionality-related characteristics.

Azonosító

P03

Kind

Szabad

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1195

Authors (legacy)

Adrienn Kazsoki1, Péter Szabó1, Barnabás Palcsó1, Károly Süvegh2, Romána Zelkó1
1 University Pharmacy Department of Pharmacy Administration, Semmelweis University, Budapest
2 Laboratory of Nuclear Chemistry, Eötvös Loránd University, Budapest