PhD Scientific Days 2017

Poster Presentation: Clinical Sciences

P26: Eosinophil cell density in the lower gastrointestinal tract of healthy individuals

Előadó neve

Kiss, Zoltán

Előadó munkahelye

1st Department of Pediatrics, Semmelweis University, Budapest, Hungary

Előadó telefonszáma

+36 70 331 76 39

Előadó e-mail címe

zoltan.kiss.bio@gmail.com

Az előadás címe

Eosinophil cell density in the lower gastrointestinal tract of healthy individuals

Szerző(k) neve és munkahelye

Zoltan Kiss1, Bálint Tél1, Péter Mátrai3, Nóra Judit Béres1, András Arató1, Katalin Eszter Müller1, Áron Cseh1, Attila J. Szabó1,2, Péter Hegyi3, Katalin Borka4, Gábor Veres1
1 1st Department of Pediatrics, Semmelweis University, Budapest, Hungary
2 MTA-SE Pediatrics and Nephrology Research Group, Budapest, Hungary
3 Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
4 2nd Dep. of Pathology, Semmelweis University, Budapest, Hungary

Szekció

Poster Presentation: Clinical Sciences

Data of the presenter

PhD school: Doctoral School of Clinical Medicine
Program: Prevention of Chronic Diseases in Childhood
Supervisor: Gábor Veres
E-mail adress of the presenter: zoltan.kiss.bio@gmail.com

Text of the abstract

Introduction: Normal density of eosinophils of the gastrointestinal (GI) tract is unknown. There are several GI diseases with elevated eosinophil density, however, in the case of the lower gastrointestinal tracts there is no consensus on the normal levels of tissue eosinophil density. Publications vary highly in the value of empiric criteria 0-50 eosinophils/HPF.

Aims: The aim of the current study was to review the available studies regarding eosinophil cell counts in healthy tissue specimen originating from lower GI fractions, in order to assess the validity of suggested diagnostic cut-offs widely used in clinical practice.

Methods: Pubmed, Scopus and Cochrane and Embase databases were screened after complex search criteria constructed with database specific syntaxes. .All studies with numerical tissue eosinophil counts were addressed in detail. Studies using acceptable histologic methods, and reported metadata according to the patients were analysed qualitatively. Measurements for whole cell count with absolute values (mm2) and appropriately published results were incorporated to the quantitative analysis.

Results: The complex search resulted in 1026 publications. Only 16 were eligible for the quantitative analysis. The overall mean cell number was 6.28 (CI 5.26, 7.29) in the colon, 14.96 (11.06, 18.87) in the small intestine. Subgroup analysis revealed an increasing tendency of the mean cell numbers from distal to proximal segments of the colon. Subgroup analysis of adult and pediatric data showed a slight difference of means with overlapping confidence intervals both in the colon and the small intestines. (Cell counts presented with field of view= 0,2 mm2).

Conclusions: The results of the meta-analysis supports the clinical experiences in tendency, but for determining the exact eosinophil cell numbers, the so far published data is not sufficient. In order to have objective reference values for diagnostic purposes, prospective studies should be conducted.

Azonosító

P26

Kind

Szabad

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1209

Authors (legacy)

Zoltan Kiss1, Bálint Tél1, Péter Mátrai3, Nóra Judit Béres1, András Arató1, Katalin Eszter Müller1, Áron Cseh1, Attila J. Szabó1,2, Péter Hegyi3, Katalin Borka4, Gábor Veres1
1 1st Department of Pediatrics, Semmelweis University, Budapest, Hungary
2 MTA-SE Pediatrics and Nephrology Research Group, Budapest, Hungary
3 Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
4 2nd Dep. of Pathology, Semmelweis University, Budapest, Hungary