PhD Scientific Days 2017

Oral Presentations: Basic Sciences II.

Postnatal remodeling of meningeal lymphatics is required for the drainage of macromolecules from the CNS

Előadó neve

Bálint, László

Előadó munkahelye

MTA-SE „Lendület” Lymphatic Physiology Research Group and Department of Physiology, Semmelweis University School of Medicine, Budapest, Hungary

Előadó telefonszáma

+36307108654

Előadó e-mail címe

balint.laszlo@med.semmelweis-univ.hu

Az előadás címe

Postnatal remodeling of meningeal lymphatics is required for the drainage of macromolecules from the CNS

Szerző(k) neve és munkahelye

László Bálint1, Zsombor Ocskay1, Bálint András Deák1, Zoltán Jakus1
1 MTA-SE „Lendület” Lymphatic Physiology Research Group and Department of Physiology, Semmelweis University School of Medicine, Budapest, Hungary

Témacsoport

molecular sciences

Szekció

Oral Presentations: Basic Sciences II.

Data of the presenter

Doctoral School: Molecular Medicine
Program: Cellular and Molecular Physiology
Supervisor: Zoltan Jakus, MTA-SE „Lendület” Lymphatic Physiology Research Group and Department of Physiology, Semmelweis University School of Medicine, Budapest, Hungary
balint.laszlo@med.semmelweis-univ.hu

Text of the abstract

Introduction: Although the classical view is that CNS lacks lymphatics, recent studies have described lymphatic structures in the dura mater. However, the developmental program and the physiological and pathological roles of meningeal lymphatics remain not understood.
Aims: In our current study we aimed to define the developmental program of meningeal lymphatics and characterize the function of these structures.
Methods: Lymphatic developmental program was followed by immunostaining. To monitor meningeal lymphatic function, 70 kDa Rhodamine-dextran was injected into the brain parenchyma followed by the assessment of the drainage to the cervical lymph nodes in lymphatic reporter animals.
Results: In our experiments, we demonstrated the presence of lymphatic structures in the meninges. Our results indicated that meningeal lymphatics develop during the postnatal period when a structural remodeling of the lymphatic structures occurs. The initiation of structural remodeling coincides with the beginning of the lymphatic mediated drainage of macromolecules from the CNS. Furthermore, we found that the drainage of macromolecules to the deep cervical lymph nodes reaches the maximum capacity two weeks past birth.
Conclusion: We revealed that postnatal structural remodeling of the developing lymphatic vessels is required for the beginning of active lymphatic drainage from the CNS to the deep cervical lymph nodes. Our results suggest that increasing lymph flow might be an important driver of the structural remodeling of meningeal lymphatics. Defining the development and function of meningeal lymphatics may lead to better understanding of the pathogenesis of diseases affecting the CNS associated with macromolecular deposition (e.g. Alzheimer’s disease).

Kind

Szabad

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1231

Authors (legacy)

László Bálint1, Zsombor Ocskay1, Bálint András Deák1, Zoltán Jakus1
1 MTA-SE „Lendület” Lymphatic Physiology Research Group and Department of Physiology, Semmelweis University School of Medicine, Budapest, Hungary