PhD Scientific Days

Poster Presentation: Clinical Sciences

P27: Heat shock protein 70 correlates with platelet number in patients with chronic obstructive pulmonary disease

Előadó neve

Dr. Odler, Balázs

Előadó munkahelye

Semmelweis University, Department of Pulmonology

Előadó telefonszáma

+36306121679

Előadó e-mail címe

odler.balazs@med.semmelweis-univ.hu

Az előadás címe

Heat shock protein 70 correlates with platelet number in patients with chronic obstructive pulmonary disease

Szerző(k) neve és munkahelye

Balázs Odler M.D.1, Vivien Somogyi1, Veronika Müller M.D., Ph.D.1
1 Semmelweis University, Department of Pulmonology, Budapest

Szekció

Poster Presentation: Clinical Sciences

Data of the presenter

Doctoral School: Semmelweis University, Doctoral School of Clinical Medicine
Program: Pulmonology
Supervisor: Prof. Veronika Müller, M.D., Ph.D.
e-mail: odler.balazs@med.semmelweis-univ.hu

Text of the abstract

Background: Chronic obstructive pulmonary disease (COPD) is characterized by airway and systemic inflammation. Recent studies have reported roles for heat shock protein 70 (Hsp70) activities in blood platelets (PLT) in maintaining hemostasis and inflammatory processes. The relationship between heat shock protein 70 and platelets in COPD was not investigated yet.

Methods: COPD patients (n=21) and healthy subject (n=12) were enrolled into clinical examinations, including lung function test, blood gas analysis, six-minute walking distance test and routine laboratory analysis. Blood cell counts were recorded in all patients. Plasma Hsp70 was assessed by ELISA.

Results: Hsp70 was significantly lower in patients with COPD as compared to healthy subjects (3.41 vs 2.83 pg/ml; p=0.02). Hsp70 showed positive correlation with forced expiratory volume in one second (FEV1%; r=0.39, p=0.03) and forced vital capacity (FVC%; r=0.40; p=0.03), while negatively correlated with residual volume (RV%; r=-0.37, p=0.04) and airway resistance (Raw%; r=-0.40, p=0.03) Moreover, a positive correlation was found with PLT count (r=0.53, p=0.01) in COPD patients, but not with mean platelet volume. In contrast, there was no difference in PLT count between the study groups.

Conclusions: COPD is characterized by decreased Hsp70 level as compared to subjects without obstructive airway disease. Decreased plasma heat shock protein 70 level seems to reflect airway inflammation (airway obstruction) and platelet count in patients with COPD.

Azonosító

P27

Kind

Szabad

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1235

Authors (legacy)