PhD Scientific Days 2017

Oral Presentations: Pharmaceutical

Taxon-specific accumulation of new, antiproliferative neo- and sesquineolignans in the fruits of Cirsium species

Előadó neve

Könye, Rita

Előadó munkahelye

Department of Pharmacognosy, Semmelweis University, Üllői út 26, Budapest 1085, Hungary

Előadó telefonszáma

+36309576163

Előadó e-mail címe

rita.konye@gmail.com

Az előadás címe

Taxon-specific accumulation of new, antiproliferative neo- and sesquineolignans in the fruits of Cirsium species

Szerző(k) neve és munkahelye

Rita Könye1,2
1 Department of Pharmacognosy, Semmelweis University, Budapest, Hungary
2 Department of Plant Anatomy, Institute of Biology, Eötvös Loránd University, Budapest, Hungary

Szekció

Oral Presentations: Pharmaceutical

Data of the presenter

Doctoral School: Doctoral School of Pharmaceutical Sciences
Program: Modern Trends in Pharmaceutical Scientific Research
Supervisors: Szabolcs Béni, Imre Boldizsár
E-mail address: rita.konye@gmail.com

Text of the abstract

Neolignans (NeLis) and sesquineolignans (SeNeLis) are plant secondary metabolites possessing cytotoxic effects against cancer cells. Our recent results confirmed the presence of these compounds in the fruits of selected Cirsium species in high amount.
The goal of this study was to extend our previous research on the lignans through the analysis of various Cirsium fruits which has not been investigated in this respect before. The results revealed (i) the presence of two new natural compounds belonging to NeLi and to SeNeLi groups and (ii) the taxon-specific accumulation of these metabolites. Thus, according to the analysis of nine Cirsium species’ fruits, samples with optimum composition for high-yield isolation of pure compounds, were selected. Namely, from the fruits of C. rivulare the new NeLi and SeNeLi compounds were obtained (characteristics to the Chamaeleon section of Cirsium genus). While the fruits of C. eriophorum was used for the isolation of the already known NeLis (balanophonin and prebalanophonin) and SeNeLis (picrasmalignan and prepicrasmalignan). These compounds were found to be characteristic for the Eriolepis section.
All the isolated compounds were tested for their antiproliferative activity (APA) against the SW480 colon adenocarcinoma cell line, confirming the (i) APA of the new NeLi and SeNeLi compounds with equal IC50 value of 40 µM and (ii) structure-antiproliferative activity relationship of these natural compounds. In fact, our results demonstrate that the new NeLi and SeNeLi possess comparable APA as their structurally related methylated derivatives (NeLi balanophonin and SeNeLi picrasmalignan); however, the corresponding open-chain structures (prebalanophonin and prepicrasmalignan) are significantly less effective with IC50 over 100 µM.

Kind

Szabad

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1291

Authors (legacy)

Rita Könye1,2
1 Department of Pharmacognosy, Semmelweis University, Budapest, Hungary
2 Department of Plant Anatomy, Institute of Biology, Eötvös Loránd University, Budapest, Hungary