PhD Scientific Days 2017

Poster Presentation: Cardiovascular

P68: Relations between atherosclerosis and AB0 blood group; von Willebrand factor and osteoprotegerin

Előadó neve

Csányi, Csilla

Előadó munkahelye

Semmelweis University, Department of Biophysics and Radiation Biology

Előadó telefonszáma

06306161538

Előadó e-mail címe

csanyicsilla90@gmail.com

Az előadás címe

Relations between atherosclerosis and AB0 blood group; von Willebrand factor and osteoprotegerin

Szerző(k) neve és munkahelye

Maria Csilla Csanyi1, Emoke Horvath2, Cosarca Mircea Catalin3, Elod Nagy4, Miklos S.Z. Kellermayer1, Jolan Harsfalvi1
1 Department of Biophysics and Radiation Biology, Semmelweis University, Budapest
2 Department of Pathology, University of Medicine and Pharmacy, Targu-Mures
3 Department of Anatomy and Embryology, University of Medicine and Pharmacy, Targu-Mures
4 Department of Biochemistry and Environmental Chemistry, University of Medicine and Pharmacy, Targu-Mures

Szekció

Poster Presentation: Cardiovascular

Data of the presenter

Doctoral Scool: Basic Medicine
Program: Cellular and molecular biophysics
Superivisor: Jolan Harsfalvi
E-mail: csanyicsilla90@gmail.com.

Text of the abstract

Atherosclerosis is a slowly progressing, pathological process involving the intima and media of large- and medium-sized arteries. Focal thickenings of the arterial wall or plaques gradually interfere with the flow during atherogenesis when thrombosis is superimposed on non-stenotic lesions, potentially leading to ischaemia of target organs and tissues.
The clinical importance of AB0 blood groups extends beyond the direct implications on transfusion and organ-transplantation compatibility. It is increasingly being recognized that individuals with non-0 blood groups may be at elevated risk of thromboembolic-, cerebrovascular ischemic events, myocardial infarction and peripheral vascular disease compared with individuals with blood group 0.
Endothelial dysfunction is an early and important trigger of atherogenesis, emerging as a response to a number of various oxidative, infectious and mechanical injuries. Von Willebrand factor (VWF) is a marker of these processes. VWF, a large multimeric glycoprotein that adheres to sub-endothelial collagen in order to catch bound platelets at high shear- and elongation forces and serves the platelet plug formation. It carries and protects coagulation FVIII that catalyze the coagulation cascade to form stable fibrin net.
Examination of 11,673 participants in the Atherosclerosis Risk in Communities (ARIC, www.cscc.unc.edu/aric/) prospective epidemiologic study demonstrated the intrinsic effects of ABO on VWF and factor VIII, independently.
Osteoprotegerin (OPG) is a dimeric glycoprotein with a multifunctional cytokine role and highly expressed in a large number of tissues. They are associated in plasma, co-localized in, and co-secreted from the Weibel-Palade bodies of the endothelial cells.
Our group evidenced that AB0 blood group type is determinant of OPG levels in blood, similar to its role on VWF.
Next we search for co-localization of the above three molecules from vessels of patients with different stage of the atherogenesis to better know the pathophysiological role of them.

Azonosító

P68

Kind

Szabad

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1305

Authors (legacy)

Maria Csilla Csanyi1, Emoke Horvath2, Cosarca Mircea Catalin3, Elod Nagy4, Miklos S.Z. Kellermayer1, Jolan Harsfalvi1
1 Department of Biophysics and Radiation Biology, Semmelweis University, Budapest
2 Department of Pathology, University of Medicine and Pharmacy, Targu-Mures
3 Department of Anatomy and Embryology, University of Medicine and Pharmacy, Targu-Mures
4 Department of Biochemistry and Environmental Chemistry, University of Medicine and Pharmacy, Targu-Mures