PhD Scientific Days

Poster Presentation: Clinical Sciences

P30: Pancreatic Lipid Deposition is Determined by Environmental Rather Than Genetic Factors: a Classical Twin Study

Előadó neve

Jermendy, Adam L.

Előadó munkahelye

MTA-SE Lendület Cardiovascular Imaging Research Group

Előadó telefonszáma

+36206663443

Előadó e-mail címe

adam.jermendy@gmail.com

Az előadás címe

Pancreatic Lipid Deposition is Determined by Environmental Rather Than Genetic Factors: a Classical Twin Study

Szerző(k) neve és munkahelye

Ádám L Jermendy1, Alexisz Panajotu1, Márton Kolossváry1, Sára Papp1, Ferenc I Suhai1, Dávid L Tárnoki2, Júlia Karády1, Béla Merkely1, Pál Maurovich-Horvat1
1 MTA-SE Lendület Cardiovascular Imaging Research Group, Budapest
2 Semmelweis University Department of Radiology, Budapest

Szekció

Poster Presentation: Clinical Sciences

Data of the presenter

Doctoral School: Basic Medicine
Program: Cardiovascular Disorders: Physiology and Medicine of Ischaemic Circulatory Diseases
Supervisor: Pál Maurovich-Horvat
e-mail: adam.jermendy@gmail.com

Text of the abstract

Aims: Intrapancreatic fat can be assessed by non-contrast-enhanced computed tomography (CT) and is associated with beta-cell dysfunction. The role of genetic and environmental factors in pancreatic lipid accumulation is unclear. Therefore, we sought to evaluate the contribution of genetics and environmental factors on pancreatic lipid content within a cohort of adult twins.
Methods: We investigated 77 twin pairs (47 monozygotic [MZ] and 30 dizygotic [DZ] same gender pairs) with a 256-slice CT-scanner. Using non-enhanced CT images we measured the average value of pancreatic attenuation (Hounsfield units [HU]) in three regions of interest. Blood samples were collected before the CT scan. Intra-pair correlations were calculated and structural equation model was used for evaluating additive genetic (A), dominant genetic (D) and unique environmental (E) components.
Results: Main clinical and laboratory findings of the twins were: age 56.1±9.4 years, BMI 27.7±5.3 kg/m2, fasting glucose 97.5±25.7 mg/dL, HbA1c 5.5±1.0% (mean±SD). Average pancreatic attenuation was 47.2±11.3 HU in MZ and 47.6±11.8 HU in DZ twins. The intra-pair correlation between HU values were stronger in MZ as compared to DZ twins (rMZ=0.498, p<0.001; rDZ=0.080, p=0.674). Using the structural equation model, a predominant environmental influence (E: 59%) and a moderate additive genetic dependence (A: 41%) was found. Dominant genetic influence was not identified (D: 0%).
Conclusion: We found a moderate genetic and a much stronger environmental dependence of pancreatic lipid accumulation in our twin cohort indicating that environmental factors and lifestyle characteristics are predominantly involved in the development of fat accumulation in the pancreas.

Azonosító

P30

Kind

Szabad

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1313

PhD Scientific Days 2017

Budapest, 11-12 April 2017