PhD Scientific Days 2017

Oral Presentations: Neurosciences

The role of prefronto-hypothalamic projections in aggressive behaviour

Előadó neve

Bruzsik, Bíborka, PhD

Előadó munkahelye

Institute of Experimental Medicine, Hungarian Academy of Sciences

Előadó telefonszáma

06302117084

Előadó e-mail címe

bruzsik.biborka@koki.mta.hu

Az előadás címe

The role of prefronto-hypothalamic projections in aggressive behaviour

Szerző(k) neve és munkahelye

Bíborka Bruzsik, László Biró, Máté Tóth, Eszter Sipos, Dóra Zelena, Diána Balázsfi, József Haller
Laboratory of Behavioural and Stress Studies, Department of Behavioural Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary

Szekció

Oral Presentations: Neurosciences

Data of the presenter

Doctoral School: Semmelweis University Szentágothai János Doctoral School of Neuroscience
Program: Neuroendocrinology
Supervisor: Máté Tóth
E-mail: toth.mate@koki.mta.hu

Text of the abstract

Aggression control is associated with many cognitive and emotional aspects processed by the prefrontal cortex (PFC). Previous studies suggested that the PFC inhibits the hypothalamic areas of aggression via indirect pathways through the amygdala. Although our former studies showed that the infralimbic and prelimbic regions of the PFC send direct projections to the mediobasal and lateral hypothalamus in rats (MBH and LH respectively), the role of these projections in aggressive behavior is still unknown. We used an optogenetic projection targeting approach to investigate the function of prefronto-hypothalamic pathways in the modulation of aggression. MBH regulates intraspecific aggression, and photostimulation of the PFC-MBH pathway resulted in elevated attack numbers accordingly. Despite of the LH is generally known for the regulation of predatory behavior, it is also implicated in the intraspecific aggression. Activation of the PFC-LH pathway altered merely the qualitative aspects of aggression, the ratio of attacks targeted onto vulnerable bodyparts of the opponents was increased in conjunction with marked deficits in attack signaling by offensive threat. Next we investigated wether the observed effects are solely aggression specifics or there is a general alterations in social interest. The photostimulation did not have impact on social behavior examined by sociability test. Overall, our data implies the PFC directly modulates the quantitavive and qualitative proporties of aggressive behavior via distinct excitatory hypothalamic projections.

Kind

Szabad

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1421

Authors (legacy)

Bíborka Bruzsik, László Biró, Máté Tóth, Eszter Sipos, Dóra Zelena, Diána Balázsfi, József Haller
Laboratory of Behavioural and Stress Studies, Department of Behavioural Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary