PhD Scientific Days 2017

Oral Presentations: Neurosciences

Context-dependent effects of early life adversities on behavioral and neural plasticity of juvenile zebrafish (Danio rerio)

Előadó neve

Varga, Zoltán Kristóf, MSc

Előadó munkahelye

Institute of Experimental Medicine, Department of Behavioural Neurobiology

Előadó telefonszáma

+3630/6654354

Előadó e-mail címe

varga.zoltan@koki.mta.hu

Az előadás címe

Context-dependent effects of early life adversities on behavioral and neural plasticity of juvenile zebrafish (Danio rerio)

Szerző(k) neve és munkahelye

Zoltán Kristóf Varga1,2, Áron Zsigmond3, Máté Varga3, József Haller1, Manó Aliczki1
1 Department of Behavioural Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
2 Janos Szentagothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary
3 Department of Genetics, Faculty of Science, Eötvös Loránd University, Budapest, Hungary

Szekció

Oral Presentations: Neurosciences

Data of the presenter

Janos Szentagothai Doctoral School of Neurosciences
Neuroendocrinology
Manó Aliczki
aliczki.mano@koki.mta.hu

Text of the abstract

Early life environment substantially influences the physiological and behavioral phenotype via neural plasticity peaks in sensitive developmental periods. However, the way in which stressful experiences induce changes underlying predictive adaptive responses are poorly understood. Here we represent a zebrafish model of neural plasticity in which we characterized an extensive behavioral metamorphosis inclusive of the maturation of anxiety-like and social behavior coincide with a highly sensitive and critical developmental time-window. We applied acute and chronic emotional stressors during the latter sensitive period in which 2 weeks of social isolation exerted robust long-term behavioral effects. Isolated animals showed lowered novelty-induced but enhanced social anxiety, while both effects were prevented by the acute administration of the anxiolytic 5-HT1a partial agonist buspirone implying the role of monoamine signaling in the latter phenomenon. To unravel the impact of serotonin and investigate possible correlations in multiple levels of neural plasticity and behavioral changes we aim to apply whole-brain enzyme-linked immunosorbent assays and immunohistochemical measurements in brain sites involved in the modulation of emotionally motivated behavior. According to our data, one may hypothetize that facing stressful stimuli during early development has a context-dependent adaptive value as individuals are able to prepare to and cope with specific environmental challenges more efficiently while fail in response to others.

Kind

Szabad

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1423

Authors (legacy)

Zoltán Kristóf Varga1,2, Áron Zsigmond3, Máté Varga3, József Haller1, Manó Aliczki1
1 Department of Behavioural Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
2 Janos Szentagothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary
3 Department of Genetics, Faculty of Science, Eötvös Loránd University, Budapest, Hungary