PhD Scientific Days 2019

Poster presentations: Oncology

Possible clinical impact of „non-specific” uptake on FDG PET/CT in paediatric Hodgkin lymphoma

Előadó neve

Dr. Jorgov, Linda

Előadó munkahelye

Semmelweis University, Nuclear Medicine Center

Előadó telefonszáma

0036702299328

Előadó e-mail címe

jorgovlinda@gmail.com

Az előadás címe

Possible clinical impact of „non-specific” uptake on FDG PET/CT in paediatric Hodgkin lymphoma

Szerző(k) neve és munkahelye

Linda Jorgov 1,2, Jean-Noёl Talbot2, Françoise Montravers2, Christine Ragu3, Judith Landmann-Parker3, Tamás Györke 1
1׃ Department of Nuclear Medicine, Semmelweis University, Budapest
2׃ Department of Nuclear Medicine and PET Centre, Hôpital Tenon, Paris
3: Department of Paediatric Oncology, Hôpital Trousseau, Paris

Bemutatás módja

Poszter

Szekció

Poster presentations: Oncology

Language of the presentation

Hungarian

Témacsoport

oncology (experimental and clinical)

Összefoglaló szövege

Possible clinical impact of „non-specific” uptake on FDG PET/CT in paediatric Hodgkin lymphoma

Our study is based on the observation that “non-specific” uptake of FDG is frequently observed in paediatric patients referred for PET/CT due to lymphoma. In the process to predict the response to chemotherapy, beside the decrease of FDG uptake in the lymphomatous lesions, the clinical significance of the “non-specific” uptake may have been overlooked.

In the PET/CT center of Hôpital Tenon (Paris), we included to our study 19 patients with the age range 6-17 years, in all cases with Hodgkin lymphoma. We evaluated the baseline and interim FDG PET/CT (iPET) after 2 cycles of chemotherapy searching for the next five “non-specific” signs: diffuse uptake of bone marrow, thymus, spleen, spinal cord and activation of the brown fat. We made visual and semiquantitative analysis (with SUVmax).

Based on the visual interpretation of the „non-specific” uptakes we had the following results: diffuse thymus hyperactivity was detected in 16% at baseline and in only 5% on the iPET; diffuse bone marrow hyperactivity was detected in 37% at baseline and in 16% on the iPET; diffuse spleen hyperactivity was detected in 48% at baseline and in 5% on the iPET; diffuse spinal cord hyperactivity was detected in 31% at baseline and in 16% on the iPET; 5% of the patients had brown adipose tissue uptake on the baseline and the iPET as well. The semiquantitative analysis showed a significantly decreased uptake on the iPET in diffuse spleen uptake and a significant increase of diffuse liver uptake which was measured as reference value.

Our preliminary conclusions: in paediatric Hodgkin lymphoma the diffuse spleen hyperactivation at baseline was more frequent than in adults, elevated diffuse thymus uptake was not frequent on the iPET and the liver uptake was elevated after 2 cycles of treatment.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4154

Presentation file URL

//docs.kmcongress.com/phd2019/eposter_6031.png

Authors (legacy)

Linda Jorgov 1,2, Jean-Noёl Talbot2, Françoise Montravers2, Christine Ragu3, Judith Landmann-Parker3, Tamás Györke 1
1׃ Department of Nuclear Medicine, Semmelweis University, Budapest
2׃ Department of Nuclear Medicine and PET Centre, Hôpital Tenon, Paris
3: Department of Paediatric Oncology, Hôpital Trousseau, Paris

Data of the presenter

Doctoral school: Clinical Medicine
Program: Lymphoma Diseases
Supervisor: Györke Tamás
email: jorgovlinda@gmail.com