PhD Scientific Days 2019

Oral presentations: Cardio-vascular sciences

Sex differences in morphological and functional characterization of athlete’s heart in a rat model

Előadó neve

Dr. Kellermayer, Dalma

Előadó munkahelye

Heart and Vascular Center, Semmelweis University

Előadó telefonszáma

+36204156011

Előadó e-mail címe

dalmakeller@gmail.com

Az előadás címe

Sex differences in morphological and functional characterization of athlete’s heart in a rat model

Szerző(k) neve és munkahelye

Dalma Kellermayer1, Attila Oláh1, Csaba Mátyás1, Mihály Ruppert1, Bálint András Barta1, Alex Ali Sayour1, Marianna Török1, Gábor Koncsos2, Zoltán Giricz2, Péter Ferdinándy2, Béla Merkely1, Tamás Radovits1
1 Herat and Vascular Center, Semmelweis University, Budapest
2 Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest

Bemutatás módja

Szóbeli

Szekció

Oral presentations: Cardio-vascular sciences

Language of the presentation

English

Témacsoport

cardio-vascular sciences

Összefoglaló szövege

Long-term exercise training is associated with characteristic morphological and functional cardiac changes, termed athlete’s heart. Recent studies suggest that sex hormones may be involved in the regulation of exercise-induced left ventricular (LV) hypertrophy. Our aim is to understand the sex-specific alterations in the heart and the underlying signaling pathways following a training period in a rat model.
Male and female rats were divided into control and swimmer groups. Athlete’s heart was induced by a 12-week-long swim training. Following the training period LV hypertrophy was assessed by echocardiography. LV pressure-volume (P-V) analysis was performed to examine in vivo cardiac function. Finally, molecular biological studies (qRT-PCR, Western blot) were performed.
Echocardiography and post-mortem measured LV weights confirmed LV hypertrophy in both genders, nevertheless it was more pronounced in females. Although there is a more significant LV hypertrophy in females, characteristic functional parameters of athletes’s heart did not show notable differences between the genders. P-V analysis showed improved contractility, mechanoenergetics and unaltered LV stiffness in both males and females. Molecular biological measurements showed a more significant induction of Akt signaling in females. There is also a characteristic sex difference in the mitogen-activated protein kinase (MAPK) pathway. The α-myosin heavy chain (MHC)/β-MHC ratio did not differ in males but increased significantly in females.
Our results confirm a more significant exercise-induced LV hypertrophy in females that has no major functional consequences compared to males. The sex-specific response of the LV to exercise is modulated by characteristic molecular pathways.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4165

Authors (legacy)

Dalma Kellermayer1, Attila Oláh1, Csaba Mátyás1, Mihály Ruppert1, Bálint András Barta1, Alex Ali Sayour1, Marianna Török1, Gábor Koncsos2, Zoltán Giricz2, Péter Ferdinándy2, Béla Merkely1, Tamás Radovits1
1 Herat and Vascular Center, Semmelweis University, Budapest
2 Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest

Data of the presenter

Doctoral School: Basic Medicine
Program: Cardiovascular Disorders: Physiology and Medicine of Ischaemic Circulatory Diseases
Supervisor: Tamás Radovits
E-mail address: dalmakeller@gmail.com