PhD Scientific Days 2020

Neurosciences II. Lectures

Modulation of Excitatory Neurotransmission by P2X7Rs in Mouse Dentate Gyrus

Előadó neve

Huang, Lumei

Előadó munkahelye

Institue of Experimental Medicine

Előadó telefonszáma

+36709413145

Előadó e-mail címe

hlmrose136@126.com

Az előadás címe

Modulation of Excitatory Neurotransmission by P2X7Rs in Mouse Dentate Gyrus

Szerző(k) neve és munkahelye

Lumei Huang1,2, János Brunner2, Vizi E. Szilveszter2, Beata Sperlagh2
1 János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary
2 Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary

Szekció

Neurosciences II. Lectures

Language of the presentation

English

Section, first choice

Neurosciences

Section, second choice

Neurosciences

Összefoglaló szövege

P2X7 receptors (P2rx7) are ligand gated ion channels and impact on several pathological processes in the brain, including neuroinflammation, cell death, hyperexcitability, changes in neurotransmitter release etc. However, the involvement of P2X7Rs in excitatory neurotransmission in dentate gyrus granule cells keeps unclear. To investigate this question, we utilized P2X7 KO mice to record NMDA-mediated miniature EPSC in granule cells. Surprisingly, we found that the amplitude and frequency significantly decreased in P2X7 KO mice compared to WT counterparts. Meanwhile, the application of selective antagonist of P2X7R (JNJ-47965567) could partly mimic the results. To summarize, P2X7Rs participate in excitatory neurotransmission via both pre-and postsynaptic sides partly through action potential-independent mechanism in adult dentate gyrus granule cells.

Additional Information

Supervisor : Sperlagh Beata
email : sperlagh@koki.hu

Bemutatás módja

Szóbeli

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4626

Start

16:30

End

16:45

Authors (legacy)

Lumei Huang1,2, János Brunner2, Vizi E. Szilveszter2, Beata Sperlagh2
1 János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary
2 Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary