PhD Scientific Days 2020

Neurosciences I. Lectures

Behavioral Effect of GABA Release from Forebrain Cholinergic Neurons

Előadó neve

Mayer, Márton, MSc

Előadó munkahelye

Institute of Experimental Medicine

Előadó telefonszáma

+3612109400/241

Előadó e-mail címe

mayer.marton@koki.mta.hu

Az előadás címe

Behavioral Effect of GABA Release from Forebrain Cholinergic Neurons

Szerző(k) neve és munkahelye

Márton I. Mayer1, Katalin E. Sós1, Virág T. Takács1, Zsuzsanna Bardóczi1, Katalin Sviatkó1, Barnabás Kocsis1, Balázs Hangya1, Manó Aliczki2, Éva Mikics2, Tamás F. Freund1, Gábor Nyiri1
1Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Budapest
2Department of Behavioural Neurobiology, Institute of Experimental Medicine, Budapest

Szekció

Neurosciences I. Lectures

Language of the presentation

English

Section, first choice

Neurosciences

Section, second choice

Neurosciences

Összefoglaló szövege

Introduction
The basal forebrain cholinergic system comprises several nuclei that provide innervation to cortical areas. It contributes to the regulation of arousal, attention and memory, including fear and extinction learning, and it is implicated in anxiety and post-traumatic stress disorder. We have recently shown that cholinergic terminals synaptically release not only acetylcholine, but GABA as well, the release of which can be modulated independently.
Aims
Although previous studies demonstrated that the alteration of GABAergic cotransmission is possible and has functional consequences in other non-cholinergic brain regions, the role of GABA release from forebrain cholinergic cells is unknown.
Method
We created a conditional knockout mouse strain (ChAT-vGAT-cKO) showing decreased GABA release from cholinergic neurons.
Results
Preliminary results from behavioral phenotyping of this strain revealed that decreased GABA release from cholinergic neurons led to increased hippocampal theta activity during sleep and increased cognitive performance in an operant learning task, possibly due to a relatively more efficient cholinergic effect. However, ChAT-vGAT-cKO mice showed significant deficits in fear extinction learning after cued fear conditioning.
Conclusion
These results suggest that inefficient GABA release from cholinergic cells may explain certain fear-related pathological conditions.

Additional Information

Supervisor: Gábor Nyiri
E-mail address: nyiri.gabor@koki.mta.hu

Bemutatás módja

Szóbeli

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4075

Start

11:50

End

12:05

Authors (legacy)

Márton I. Mayer1, Katalin E. Sós1, Virág T. Takács1, Zsuzsanna Bardóczi1, Katalin Sviatkó1, Barnabás Kocsis1, Balázs Hangya1, Manó Aliczki2, Éva Mikics2, Tamás F. Freund1, Gábor Nyiri1
1Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Budapest
2Department of Behavioural Neurobiology, Institute of Experimental Medicine, Budapest