PhD Scientific Days 2020

Neurosciences II. Lectures

Examining the Role of the Subthalamic Nucleus in a Stop Signal Reaction Time Task in Patients with Parkinson's Disease

Előadó neve

Dr. Hegedüs, Panna

Előadó munkahelye

Institute of Experimental Medicine

Előadó telefonszáma

+36706242016

Előadó e-mail címe

hegedus.panna@koki.mta.hu

Az előadás címe

Examining the Role of the Subthalamic Nucleus in a Stop Signal Reaction Time Task in Patients with Parkinson's Disease

Szerző(k) neve és munkahelye

Presenting author: Panna Hegedüs1,2
Author and co-authors: Panna Hegedüs1,2, Tamás Laszlovszky1,2, Gertrúd Tamás3, László Halász4, Virág Bokodi4, György Perczel4, András Széll1, István Ulbert4,5,6, Dániel Fabó4, Loránd Erőss4, Balázs Hangya1

Affiliation details:
1Lendület Laboratory of Systems Neuroscience, Institute of Experimental Medicine, Budapest, Hungary
2János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary
3Department of Neurology, Semmelweis University, Budapest, Hungary.
4Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary
5Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary;
6Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Budapest, Hungary

Szekció

Neurosciences II. Lectures

Language of the presentation

English

Section, first choice

Neurosciences

Section, second choice

Theoretical and Translational Medicine

Összefoglaló szövege

Parkinson’s disease (PD) is one of the most common neurodegenerative disorders. While the symptoms are initially dominated by motor impairment, the overwhelming majority of PD patients develop cognitive impairment with the progression of the disease.
The subthalamic nucleus (STN) is modulated by frontal cortex and thought to mediate motor responses during decision making. Therefore, during decision conflict, the precise timing of STN activation may be crucial for response inhibition.
In our study, we investigated the role of STN neural activity in decision making, focusing on its proposed role on inhibitory control. PD patients performed a stop-signal reaction time task, in which two numbers were presented on a screen and the patients had to press the corresponding buttons on a button box as fast as possible. After a subset of the cues, a stop instruction was presented, indicating that the patient had to withhold the motor response. The patients performed this task before, during and after DBS implantation surgery. During surgery, extracellular unit recording from the STN and frontal EEG was co-registered. A subpopulation of STN neurons were suppressed during button presses, consistent with their role in the indirect basal ganglia pathway. Importantly, a subset of STN neurons showed differential activity upon cue presentation before successful and unsuccessful stops, thus predictive of successful inhibition. This activation pattern is consistent with the proposed role of the STN in inhibitory control during decision making. Simultaneous EEG recordings may reveal how STN coherence with frontal cortical population activity mediates successful and unsuccessful response inhibition.

Additional Information

Supervisor:
Balázs Hangya
hangya.balazs@koki.mta.hu

Bemutatás módja

Szóbeli

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4647

Start

18:00

End

18:15

Authors (legacy)

Presenting author: Panna Hegedüs1,2
Author and co-authors: Panna Hegedüs1,2, Tamás Laszlovszky1,2, Gertrúd Tamás3, László Halász4, Virág Bokodi4, György Perczel4, András Széll1, István Ulbert4,5,6, Dániel Fabó4, Loránd Erőss4, Balázs Hangya1

Affiliation details:
1Lendület Laboratory of Systems Neuroscience, Institute of Experimental Medicine, Budapest, Hungary
2János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary
3Department of Neurology, Semmelweis University, Budapest, Hungary.
4Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary
5Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary;
6Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Budapest, Hungary