PhD Scientific Days 2020

Mental Sciences I. Posters

Potential Purine Biomarkers in Plasma, in Mental Disorders

Előadó neve

Kristof, Zsuliet

Előadó munkahelye

Institute of Experimental Medicine

Előadó telefonszáma

+3630/1734453

Előadó e-mail címe

zsuliet.kristof@gmail.com

Az előadás címe

Potential Purine Biomarkers in Plasma, in Mental Disorders

Szerző(k) neve és munkahelye

Zsuliet Kristof, Institute of Experimental Medicine

Szekció

Mental Sciences I. Posters

Language of the presentation

English

Section, first choice

Mental Sciences

Section, second choice

Neurosciences

Összefoglaló szövege

The aim of our study is to identify potential biomarkers in the plasma, which are associated with the purinergic signaling. P2X7 is an ATP-gated cation channel localized in different cell types in the central nervous system. P2X7 receptor activity, by regulating the release of proinflammatory cytokines, may be involved in the pathophysiology of different mental disorders, including schizophrenia.
In this study, we are measuring the ATP and adenosine levels of 120 schizophrenic patients and 40 healthy controls from a small amount of blood; and we administer the PANSS interview. After signing the official informed consent form, a nurse is taking 150-200 μL blood from the patient’s fingertip, which sample is analysed immediately with a SMARTChip biosensor. Besides, we are also collecting 3.5 ml blood, from which the P2X7 concentration is measured with the use of an ELISA kit.
Our two main questions are: 1.) Is there any difference in the level of adenosine between healthy controls and schizophrenic patients? And 2.) Is there any correlation between the level of purines and the PANSS scores?
The preliminary results suggest that there is no significant difference in the level of purines between healthy controls and schizophrenic patients. However, a certain pattern in the correlations can be observed: the correlation between the level of adenosine and the PANSS scores is slightly positive in every case, while these correlations with the ATP levels are slightly negative.

Additional Information

Supervisors:
Beata Sperlagh Prof.
sperlagh.beata@koki.mta.hu

Istvan Bitter Prof.

Bemutatás módja

Poszter

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4648

Start

11:19

End

11:22

Authors (legacy)

Zsuliet Kristof, Institute of Experimental Medicine