PhD Scientific Days 2020

Clinical Medicine I. Lectures

Application of a RGB Autofluorescence Based Techniques for the Non-invasive Screening of Pigmented Skin Lesions

Előadó neve

Dr. Bozsányi, Szabolcs

Előadó munkahelye

Semmelweis University- Department of Dermatology, Venerology and Dermatooncology

Előadó telefonszáma

0036702037109

Előadó e-mail címe

bozsanyiszabolcs@gmail.com

Az előadás címe

Application of a RGB Autofluorescence Based Techniques for the Non-invasive Screening of Pigmented Skin Lesions

Szerző(k) neve és munkahelye

Szabolcs Bozsányi1, Norbert Kiss1, Luca Fésűs1, Pálma Anker1, Antal Jobbágy1, Sára Zakariás1, Klára Farkas1, Eszter Horváth1, Alíz Szabó1, Dóra Plázár1, Kende Lőrincz1, András Bánvölgyi1, Nóra Gyöngyösi1, Enikő Kuroli1, Marta Lange2, Emilija V. Plorina2, Janis Spigulis2, Márta Medvec1z, Norbert Wikonkál1

1: Semmelweis University- Department of Dermatology, Venerology and Dermatooncology, Budapest, Hungary
2: University of Latvia, Riga, Latvia

Szekció

Clinical Medicine I. Lectures

Language of the presentation

English

Section, first choice

Clinical Medicine

Section, second choice

Pathology and Oncology

Összefoglaló szövege

Introduction: In the recent years more and more non-invasive imaging methods are available to assess different skin diseases in all over the world. From the countless indications of these methods the differential diagnosis of benign pigmented skin lesions and melanoma is one of the most relevant topics in the field of dermato-oncology.
Aim: We utilized a handheld device operating based on the principles of RGB autofluorescence using LED (light emitting diode) light to detect various skin lesions.
Method: We performed the study in two different centres, in the Department of Dermatology, Venerology and Dermatooncology of Semmelweis University, and in the Oncology Centre of Latvia in Riga. We examined 1600 pigmented lesions with this method and documented these cases with clinical and dermoscopic photographs. We used LED light four different wavelengths of 405 nm, 526 nm, 663 nm and 964 nm, which excite different components in the skin a based on their distinct excitation spectra. The 526 nm is absorbed mainly by the hemoglobin, the 663 nm is by the melanin, while 964 nm grants deeper penetration depth . The light at the wavelength of 405 nm induces certain endogenous fluorophores in the skin including keratin, flavins and elastin. From these data a Matlab based software (MathWorks Inc., Natick, MA, USA) counts a p parameter to estimate the risk of melanoma. We analyzed the p parameters using Student’s two-sample t-test.
Results: The device proved to be suitable to differentiate melanoma from other benign pigmented skin lesions using the parameter p. The value of the parameter p refers to the risk of the lesions, and the range between 0,5 and 1 means the high risk group. Among the melanoma cases the p parameter had an average value of 1,407 (n=21) while it was 0,17 among the benign lesions.
Conclusion: The present device is a potential screening tool in the field of to differentiate benign pigmented skin lesions from melanoma. In addition to its low cost and safe application, the exposition time of 40 seconds is short enough to use it in the everyday clinical practice. Also, p parameter is calculated within one minute following the image exposition. Thus, this device could be applied as a potential screening tool for the assessment of skin lesions at the offices of general practitioners.

Scholarships and funding
EFOP-3.6.3-VEKOP-16-2017-00009
and
New National Excellence Program of the Ministry for Innovation and Technology ÚNKP-19-3-II-SE-15

Additional Information

Suvervisor: Prof.Dr.Norbert Wikonkál
e-mail: wikonkal.norbert@med.semmelweis-univ.hu

Bemutatás módja

Szóbeli

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4655

Start

10:20

End

10:35

Authors (legacy)

Szabolcs Bozsányi1, Norbert Kiss1, Luca Fésűs1, Pálma Anker1, Antal Jobbágy1, Sára Zakariás1, Klára Farkas1, Eszter Horváth1, Alíz Szabó1, Dóra Plázár1, Kende Lőrincz1, András Bánvölgyi1, Nóra Gyöngyösi1, Enikő Kuroli1, Marta Lange2, Emilija V. Plorina2, Janis Spigulis2, Márta Medvec1z, Norbert Wikonkál1

1: Semmelweis University- Department of Dermatology, Venerology and Dermatooncology, Budapest, Hungary
2: University of Latvia, Riga, Latvia