PhD Scientific Days 2020

Theoretical and Translational I. Lectures

Salt Induced Three Dimensional Electrospun Fibrous Matrices

Előadó neve

Juhász, Ákos György, MSc

Előadó munkahelye

Semmelweis University, Department of Biophysics and Radiation Biology, Laboratory of Nanochemistry

Előadó telefonszáma

+3620/969-1882

Előadó e-mail címe

juhaszakosgyorgy91@gmail.com

Az előadás címe

Salt Induced Three Dimensional Electrospun Fibrous Matrices

Szerző(k) neve és munkahelye

Akos Gyorgy Juhasz 1,2, Kristof Molnar 1,3, Abdenacer Idrissi 2, Angela Jedlovszky-Hajdu 1
1 Semmelweis University, Department of Biophysics Radiation Biology, Laboratory of Nanochemistry, Budapest, Hungary
2 University of Lille, Faculty of Sciences and Technology, Chemistry Department, Laboratory of Infrared and Raman Spectrochemistry, Lille, France
3 The Ohio State University, Department of Food, Agricultural and Biological Engineering, College of Food, Agricultural, and Environmental Sciences, Wooster, OH

Szekció

Theoretical and Translational I. Lectures

Language of the presentation

English

Section, first choice

Theoretical and Translational Medicine

Section, second choice

Molecular Sciences

Összefoglaló szövege

Electrospinning is a widely investigated and used technique for creating nano and microfibres which has a wide range of medical and pharmaceutical applications. For cell culturing and tissue engineering it is a greatly investigated method because it resembles the extracellular matrix. Changing the electrospinning parametres we affect the properties of these systems to fine tune it for our needs. To create a high porosity fibrous mesh for culturing different cells in a suitable three dimensional way, we need to step forward from conventional electrospinning. My aim was to find a reproducible way of creating three dimensional fluffy structures from polysuccinimide which is a biocompatible and biodegradable polymer, in the presence of different concentrations of LiCl, MgCl2 and CalCl2 in the solution.
Ion-ion and ion-solvent (dimethylformamide) interactions were characterised using vibration spectroscopy and quantum calculations. Also, structural changes of the fibrous mesh by macroscopic and SEM (Scanning Electron Microscopy) images were recorded.
CaCl2, MgCl2 and LiCl were identified as salts that promote fluffy structure upon mixing in polysuccinimide-dimethylformamide solutions used for electrospinning. FTIR and computational investigation showed that there is a strong interaction between their respective ionic components and the solvent. Furthermore, according to our data the most important thing is the quality of the salt and through that its interaction with the solvent used for electrospinning.

Additional Information

Supervisor: Angéla Jedlovszky-Hajdú
E-mail address: hajdu.angela@med.semmelweis-univ.hu

Bemutatás módja

Szóbeli

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4663

Start

10:35

End

10:50

Authors (legacy)

Akos Gyorgy Juhasz 1,2, Kristof Molnar 1,3, Abdenacer Idrissi 2, Angela Jedlovszky-Hajdu 1
1 Semmelweis University, Department of Biophysics Radiation Biology, Laboratory of Nanochemistry, Budapest, Hungary
2 University of Lille, Faculty of Sciences and Technology, Chemistry Department, Laboratory of Infrared and Raman Spectrochemistry, Lille, France
3 The Ohio State University, Department of Food, Agricultural and Biological Engineering, College of Food, Agricultural, and Environmental Sciences, Wooster, OH