PhD Scientific Days 2020

Neurosciences II. Lectures

Resting State fMRI Correlates of Mental Fatigue and Reward-Induced Improvement in Task Performance

Előadó neve

Matuz, András

Előadó munkahelye

Institute of Behavioural Sciences, Medical School, University of Pécs

Előadó telefonszáma

20/250-8446

Előadó e-mail címe

andras.matuz@aok.pte.hu

Az előadás címe

Resting State fMRI Correlates of Mental Fatigue and Reward-Induced Improvement in Task Performance

Szerző(k) neve és munkahelye

András Matuz1, Árpád Csathó1

1 Institute of Behavioural Sciences, Medical School, University of Pécs, Pécs

Szekció

Neurosciences II. Lectures

Language of the presentation

English

Section, first choice

Neurosciences

Section, second choice

Mental Sciences

Összefoglaló szövege

Instruction
Sustaining attention for prolonged periods of time can lead to a decay in performance and an increase in subjective fatigue, labelled in the literature as Time-on-Task effect (ToT) or mental fatigue. However, previous studies showed that the ToT effect is reversible by increasing task rewards.
Aims
In this study, we explored the link between reward-induced changes in task performance after prolonged performance of the psychomotor vigilance task and resting state functional connectivity (FC) obtained by fMRI.
Methods
Thirty-nine healthy participants underwent resting state functional magnetic resonance imaging, while they were instructed to fixate on a cross with eyes open. Then, participants performed the 15-min version of the psychomotor vigilance task out of scanner (ToT-period) followed by a 5-min rewarded run of the same task.
Results
Participants showed robust ToT effects indicated by slower reaction times and higher subjective fatigue. On the other hand, a significant improvement in performance was found in the rewarded run possibly due to reward-induced increase in motivation. At the neural level, we found that the magnitude of the ToT effect was negatively related to FC of the bilateral putamen and the cerebellum. In addition, graph theoretical analyses showed that the ToT effect was negatively correlated with global efficiency but positively correlated with clustering coefficient, both indicating that higher functional integrity predicts lower sensitivity to the detrimental effects of ToT. Critically, reward-induced improvements in performance were positively associated with the FC of the right lateral sensorimotor region with the right anterior insula, left anterior supramarginal gyrus, left intraparietal sulcus and left insular cortex.
Discussion
Our results suggest that the positive effects of reward manipulation on restoring one’s performance are associated with increased FC between brain areas involved in visual attention, perceptual-motor coordination and the processing of costs and punishments.

Additional Information

Supervisor: Árpád Csathó, arpad.csatho@aok.pte.hu

Bemutatás módja

Szóbeli

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4664

Start

17:30

End

17:45

Authors (legacy)

András Matuz1, Árpád Csathó1

1 Institute of Behavioural Sciences, Medical School, University of Pécs, Pécs