PhD Scientific Days 2020

Clinical Medicine II. Lectures

The Concept of an Integrated Central Blood Pressure- Aortic Stiffness Score, a Potential New Tool for Cardiovascular Risk Stratification: Further Results in Chronic Kidney Disease

Előadó neve

Dr. Batta, Dóra

Előadó munkahelye

Department of Family Medicine, Semmelweis University, Budapest

Előadó telefonszáma

+36302107562

Előadó e-mail címe

batta.dori@gmail.com

Az előadás címe

The Concept of an Integrated Central Blood Pressure- Aortic Stiffness Score, a Potential New Tool for Cardiovascular Risk Stratification: Further Results in Chronic Kidney Disease

Szerző(k) neve és munkahelye

Dóra Batta1, Ádám Tabák2, Beáta Kőrösi1, Orsolya Cseprekál3, József Egresits4, András Tislér2, János Nemcsik1,5
1 Department of Family Medicine, Semmelweis University, Budapest;
2 1st Department of Medicine, Semmelweis University, Budapest;
3 Department of Transplantation and Surgery, Semmelweis University, Budapest;
4 Innere Medizin und Kardiologie Klinikum Klagenfurt, Klagenfurt am Wörthersee, Austria.
5 Health Service of Zugló (ZESZ), Budapest

Szekció

Clinical Medicine II. Lectures

Language of the presentation

Hungarian

Section, first choice

Clinical Medicine

Section, second choice

Clinical Medicine

Összefoglaló szövege

Introduction: Arterial vascular stiffness and central blood pressure are potential tools in cardiovascular risk assessment. Different values resulting from many available methods, however, make the emergence of an international consensus difficult.
Objective: Our aim was to study the predictive power of Integrated Central Blood Pressure- Aortic Stiffness (ICPS) risk categories on cardiovascular (CV) mortality in end-stage renal disease (ESRD) patients on hemodialysis therapy.
Method: In our retrospective cohort study 91 patients were involved from two dialysis centers. Pulse wave velocity (PWV), central systolic blood pressure (cSBP) and central pulse pressure (cPP) were measured with tonometric method, patients were followed for a median of 29.5 months and CV mortality was registered. Patients were classified into tertiles based on their PWV, cSBP and cPP values. After the analysis of the predictive values of the tertiles of the identical parameters, patients were scored. One score was given, when a patient had a third tertile value of cSBP or a second or third tertile value of PWV or cPP. Then the CV outcome was analyzed with Cox regression analysis of the groups of patients with different ICPS scores and three ICPS risk categories were defined: average (0-1 point), high (2 points) and very high (3 points).
Results: During follow-up 31 events occurred. After adjustment for multiple factors, compared with the average ICPS risk category group (n=35; 38%), those, who were in the high risk group (n=33; 30%) showed a tendency for significantly higher hazard ratio (HR) of CV mortality (HR=2.62, 95% confidence interval (CI):0.82-8.43), while patients in the very high ICPS risk category (n=23; 21%) had a markedly increased risk (HR=10.03, CI:1.67-60.42).
Conclusions: The ICPS risk categories can help in the identification of ESRD patients with high CV risk.

Additional Information

Supervisor: János Nemcsik
E-mail address: janos.nemcsik@gmail.com

Bemutatás módja

Szóbeli

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

2713

Start

11:50

End

12:05

Authors (legacy)

Dóra Batta1, Ádám Tabák2, Beáta Kőrösi1, Orsolya Cseprekál3, József Egresits4, András Tislér2, János Nemcsik1,5
1 Department of Family Medicine, Semmelweis University, Budapest;
2 1st Department of Medicine, Semmelweis University, Budapest;
3 Department of Transplantation and Surgery, Semmelweis University, Budapest;
4 Innere Medizin und Kardiologie Klinikum Klagenfurt, Klagenfurt am Wörthersee, Austria.
5 Health Service of Zugló (ZESZ), Budapest