PhD Scientific Days 2020

Neurosciences I. Posters

Parallel Connections in the Frontal Thalamo-cortical System of Mouse

Előadó neve

Magyar, Aletta, MSc

Előadó munkahelye

Research Centre for Natural Sciences

Előadó telefonszáma

+36306628310

Előadó e-mail címe

magyaraletta92@gmail.com

Az előadás címe

Parallel Connections in the Frontal Thalamo-cortical System of Mouse

Szerző(k) neve és munkahelye

Magyar Aletta 1, 3, Karola Költő 1, 2,Mónika Szabó 1, 3, Anna Fehér 1, Judit Berczik 1, 3, Gyula Balka 4, Lilla Dénes 4, Ofer Yizhar 5, Ferenc Mátyás 1,6

1, Neuronal Network and Behaviour Res. Group, Res. Ctr. For Natural Sciences, Budapest, Hungary
2, Eötvös Lorand University, Faculty of Science, Budapest, Hungary
3, János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary
4, Department of Pathology, University of Veterinary Medicine, Budapest, Hungary
5, Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
6, Departmen of Anatomy and Histology, University of Veterinary Medicine, Budapest, Hungary

Szekció

Neurosciences I. Posters

Language of the presentation

English

Section, first choice

Neurosciences

Section, second choice

Neurosciences

Összefoglaló szövege

The frontal thalamo-cortical system plays important roles in many cognitive processes. Any damage or dysfunction in this network can lead to neurological disorders like anxiety and schizophrenia. Although the large dataset regarding this system found in the literate, the precise anatomical organization between the involved medial thalamic and frontal cortical regions is missing. As the presence or absence of a calcium binding protein, the calretinin (CR) characterizes distinct medial thalamic populations (CR+, CR-negative), we used cell type- and target-specific approaches in Calb2(CR)-Cre mice to anatomically dissect the frontal thalamo-cortical system. CR+ and CR- thalamic neurons gave rise to a rather nonoverlapping axon arborizations in the cortex: while CR+ cells preferentially innervated prelimbic, infralimbic, orbital and insular cortices, CR- neurons sent axons to the cingulate and secondary cortical areas. The layer-specific distribution of their axonal inputs was also different in those cortical areas which were targeted by both populations. In addition, their subcortical projections were also distinct. While CR+ cells targeted limbic structures like ventral striatum, amygdala and ventral hippocampus/subiculum, CR- neurons avoided these regions. Besides that, distinct CR+ populations also showed some level of heterogeneity in their cortical and subcortical connectivity. For example, the amygdala- and the nucleus accumbens projecting medial thalamic cells innervated distinct domains of the bed nucleus stria terminalis and different layers of the frontal cortical regions, revealed by a retroanterograde viral approach. Altogether these findings indicate that the frontal thalamo-cortical system is organized in a complex manner by several parallel thalamic routes.

Additional Information

Supervisor: Ferenc Mátyás
E-mail:matyas.ferenc@ttk.hu

Bemutatás módja

Poszter

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4066

Start

12:53

End

12:56

Authors (legacy)

Magyar Aletta 1, 3, Karola Költő 1, 2,Mónika Szabó 1, 3, Anna Fehér 1, Judit Berczik 1, 3, Gyula Balka 4, Lilla Dénes 4, Ofer Yizhar 5, Ferenc Mátyás 1,6

1, Neuronal Network and Behaviour Res. Group, Res. Ctr. For Natural Sciences, Budapest, Hungary
2, Eötvös Lorand University, Faculty of Science, Budapest, Hungary
3, János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary
4, Department of Pathology, University of Veterinary Medicine, Budapest, Hungary
5, Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
6, Departmen of Anatomy and Histology, University of Veterinary Medicine, Budapest, Hungary