PhD Scientific Days 2020

Pharmaceutical Sciences I. Lectures

The Application of 3D Printing in the Formulation of Personalized Drug Delivery Systems

Előadó neve

Dr. Basa, Bálint

Előadó munkahelye

Semmelweis University Department of Pharmaceutics

Előadó telefonszáma

+36309511779

Előadó e-mail címe

kysbasa@gmail.com

Az előadás címe

The Application of 3D Printing in the Formulation of Personalized Drug Delivery Systems

Szerző(k) neve és munkahelye

Bálint Basa - Semmelweis University Department of Pharmaceutics
Géza Jakab - Semmelweis University Department of Pharmaceutics
Emese Balogh - Semmelweis University Department of Pharmaceutics
István Antal - Semmelweis University Department of Pharmaceutics

Szekció

Pharmaceutical Sciences I. Lectures

Language of the presentation

English

Section, first choice

Pharmaceutical Sciences

Section, second choice

Pharmaceutical Sciences

Összefoglaló szövege

The interest toward additive manufacturing is growing considering the formulation of personalized medicines.3D printing is commonly an additive process, which results in layer-by-layer built objects. The most common types are Photopolymerization, Selective Laser Sintering (SLS),Fused Deposition Modelling (FDM).The first 3D printed orodispersible tablet was approved by the FDA in 2015.
The objective of our study was to design and print biodegradable drug delivery systems. Commercially available filament materials were screened as well as the print settings were optimized. In addition, the influence of design parameters(e.g. wall thickness, morphology, pores) on drug delivery in case of model drugs was investigated. Moreover, the applicability of matrix polymers and gelling agents in the process of 3D printing was studied. There were some formulations aiming the study of dose proportionality, in order to expand the opportunities of personalized medication.
The designed polygon models were sliced(Ultimaker Cura 3.6,Netherlands) and an FDM printer(Creality Ender 3, China) was used to print the objects with polylactic acid(PLA) and polyvinyl alcohol(PVA) based filaments. The investigated printing parameters were the following: temperature of the extruder:170-250 ºC; bed temperature:50-110 ºC; printing speed:5-40 mm/s; cooling fan performance:30-100 % and infill: 0.1-0.4 mm. The dissolution profile of the model drug was examined in different pH media(1.2; 4.5; 6.8) recording also the particle size distribution of solid filaments.
As a result of this study, the morphology of PLA and PVA based carriers were optimalized via the proper print settings. According to the biorelevant dissolution studies, the PVA based printlets form colloidal dispersion in aqueous media without reference to H+ concentration.(Z-avg Aquapur: 235.13±2.12nm;Z-avg pH=1.2: 245.85±11.67nm; Z- avg pH=6.8:249.57±11.67 nm). The drug release was significantly influenced by the morphology and layer characteristics of the carriers, the presence and number of pores and excipients. The released API contents of equally increased dose samples showed great linearity with high R2 values(ranging from 0.983 to 0.992)which confirms the dose proportionality.
These adjustable properties lead to wide range of opportunities to precisely tailor the release profile of the 3D printed drug delivery systems.

Additional Information

Supervisor: István Antal
E-mail: antal.istvan@pharma.semmelweis-univ.hu

Bemutatás módja

Szóbeli

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4696

Start

10:40

End

10:55

Authors (legacy)

Bálint Basa - Semmelweis University Department of Pharmaceutics
Géza Jakab - Semmelweis University Department of Pharmaceutics
Emese Balogh - Semmelweis University Department of Pharmaceutics
István Antal - Semmelweis University Department of Pharmaceutics