PhD Scientific Days 2020

Dental Sciences Lectures

Maternal‐related Factors in the Origin of Isolated Cleft Palate

Előadó neve

Dr. Ács, Lili

Előadó munkahelye

Semmelweis University Faculty of Dentistry, Department of Paediatric Dentistry and Orthodontics

Előadó telefonszáma

+36309900219

Előadó e-mail címe

acslili18@gmail.com

Az előadás címe

Maternal‐related Factors in the Origin of Isolated Cleft Palate

Szerző(k) neve és munkahelye

Lili Ács1, Dorottya Bányai1, Bálint Nemes1, Krisztián Nagy3, Nándor Ács2, Ferenc Bánhidy2, Noémi Rózsa1

1 Department of Paediatric Dentistry and Orthodontics, Semmelweis University Faculty of Dentistry, Budapest
2 Department of Obstetrics and Gynaecology, Semmelweis University School of Medicine, Budapest
3 1st Department of Paediatrics, Semmelweis University School of Medicine, Budapest

Szekció

Dental Sciences Lectures

Language of the presentation

Hungarian

Section, first choice

Dentistry

Section, second choice

Clinical Medicine

Összefoglaló szövege

Introduction: Isolated cleft palate (CPO) is the rarest form of oral clefting affecting 1 to 25 per 10,000 newborns worldwide. There is increasing evidence for the different pathogenetic backgrounds of CPO and cleft lip with or without cleft palate. The role of environmental factors in the origin of nonsyndromic and syndromic CPO is unclear in most patients.
Aims: The aim of this study was to estimate possible maternal risk factors in the origin of CPO.
Method: The Hungarian Case-Control Surveillance of Congenital Abnormalities contains data of 32,345 birth defect cases and 57,231 control newborns. The study samples included 751 cases with isolated CPO, 1,196 matched controls and 57,231 population controls. Maternal diseases during pregnancy in cases and population controls were compared and adjusted ORs with 95% CI were calculated in a multivariable unconditional logistic regression model.
Results: Beyond the well-known robust female excess (58.9%) – maternal smoking (OR with 95% CI: 2.34, 1.94-2.81) medically recorded maternal anaemia (OR: 1.8, 1.3-2.7), threatened abortion (OR: 4.9, 3.1-7.9) and excessive vomiting in pregnancy (OR: 3.2, 2.6-4.0) were associated with a higher risk for CPO in the offspring. An elevated risk was found in Graves-disease (OR: 4.30, 1.74-10.62), epilepsy (OR: 4.64, 2.44-8.82), migraine (OR: 2.82, 1.18-6.76) and essential hypertension (OR: 2.33, 1.32-4.10). Among acute diseases common cold (OR: 4.94, 3.48-7.03), acute respiratory infections (OR: 4.20, 1.49-11.82), influenza (OR: 2.95, 1.75-4.95), pulpitis (OR: 7.85, 2.80-22.03), cholecystitis (OR: 3.15, 1.16-8.60), acute urinary tract infections (OR: 4.08, 2.22-7.49) and pelvic inflammatory diseases (OR: 3.93, 1.62-9.53) during pregnancy also were associated with an increased risk for developing CPO.
Conclusion: The findings of this study suggest that maternal diseases and lifestyle factors during the first trimester play a significant role in the development of isolated cleft palate.

Additional Information

Supervisor: Krisztián Nagy
E-mail adress: nagykrisztian@me.com

Bemutatás módja

Szóbeli

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4729

Start

10:25

End

10:40

Authors (legacy)

Lili Ács1, Dorottya Bányai1, Bálint Nemes1, Krisztián Nagy3, Nándor Ács2, Ferenc Bánhidy2, Noémi Rózsa1

1 Department of Paediatric Dentistry and Orthodontics, Semmelweis University Faculty of Dentistry, Budapest
2 Department of Obstetrics and Gynaecology, Semmelweis University School of Medicine, Budapest
3 1st Department of Paediatrics, Semmelweis University School of Medicine, Budapest