PhD Scientific Days 2020

Mental Sciences II. Posters

Investigation of the Cognitive Perfomance in Adult Attention Deficit/Hyperactivity Disorder and Borderline Personality Disorder Using the CANTAB Neuropsychological Software

Előadó neve

Dr. Szilvia, Somogyi

Előadó munkahelye

Semmelweis University, Department of Psychiatry and Psychotherapy

Előadó telefonszáma

+36303057842

Előadó e-mail címe

somogyi.szilvia@med.semmelweis-univ.hu

Az előadás címe

Investigation of the Cognitive Perfomance in Adult Attention Deficit/Hyperactivity Disorder and Borderline Personality Disorder Using the CANTAB Neuropsychological Software

Szerző(k) neve és munkahelye

Szilvia Somogyi, Semmelweis University, Department of Psychiatry and Psychotherapy/Budapest
Eszter Kenézlői, Semmelweis University, Department of Psychiatry and Psychotherapy/Budapest
Lívia Balogh, Semmelweis University, Department of Psychiatry and Psychotherapy/Budapest
Zsófia Nemoda, Semmelweis University, Department of Medical Chemistry, Molecular Biology and Pathobiochemistry
János Réthelyi, Semmelweis University, Department of Psychiatry and Psychotherapy/Budapest

Szekció

Mental Sciences II. Posters

Language of the presentation

Hungarian

Section, first choice

Mental Sciences

Section, second choice

Neurosciences

Összefoglaló szövege

Introduction: In our reserach we study the cognitive performance and the phenomenon of impulsivity, which are hypothetised potential endophenotypes in psychiatric disorders. We investigated patients with Adult Attention Deficit/Hyperactivity Disorder (aADHD) and Borderline Personality Disorder (BPD), because impulsivity is a main symptom for both diagnoses, however the etiology is different.
Aims: The aim of our presentation is to summarize two studies, with the aim to identify potential endophenotypes and their genetic associations. The first study compared the cognitive performance and the level of impulsivity in aADHD, BPD and control groups (CG). The second study focus on the genetic association of impulsivity, using a dimensional approach in an aADHD sample. The gene that we investigated, was the norepinephrine-transporter-gene (NET/SCL6A2).
Method: Three groups were included in the first study: aADHD (31 patients), BPD (24 patients) and control groups (39 participants). The diagnosis in the patient groups were set up according to DSM-5 criteria. To characterise the cognitive performance the CANTAB (Cambridge Neurocognitive Test Automated Battery) software was used. Participants were recruited from the Department of Psychiatry and Psychotherapy, Semmelweis University. The genetic associtation study included 148 aADHD patients. The three investigated single-nucleotide polymorphisms (SNP) of SCL6A2 were the following: in the promoter region rs28386840, and rs2242446, and the intronic rs3785143. For clinical phenotype a subjective measurement was used: the Conners’ Adult ADHD Rating Scale (CAARS). To investigate data, GLM analyses were performed.
Results: We found several differences in cognitive performance between patients and the CG. In working memory, working memory capacity, and response inhibition domains BPD and aADHD groups performed poorer than the CG. In the second study we found significant associations of impulsivity and all of the examined NET polimorphysms. The rs3785143 showed a relationship not only with impulsivity but also the severity of other ADHD symptoms.
Conclusion: Based on our results, we found that CANTAB is able to give accurate phenotypic data which can be used as potential endophenotypes. Our further plans is to increase the number of samples, and begin to describe the genetic basis of CANTAB-based cognitive differences.

Additional Information

This study is funded by the Hungarian National Research Development and Innovation Office (NKFI/OTKA -129195).

Bemutatás módja

Poszter

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4743

Start

12:31

End

12:34

Authors (legacy)

Szilvia Somogyi, Semmelweis University, Department of Psychiatry and Psychotherapy/Budapest
Eszter Kenézlői, Semmelweis University, Department of Psychiatry and Psychotherapy/Budapest
Lívia Balogh, Semmelweis University, Department of Psychiatry and Psychotherapy/Budapest
Zsófia Nemoda, Semmelweis University, Department of Medical Chemistry, Molecular Biology and Pathobiochemistry
János Réthelyi, Semmelweis University, Department of Psychiatry and Psychotherapy/Budapest