PhD Scientific Days 2020

Theoretical and Translational II. Posters

Novel Integrative Methods to Identify Therapeutic Targets and Compounds for Treating Kidney Fibrosis

Előadó neve

István Márton, Takács

Előadó munkahelye

1st Department of Paediatrics, Semmelweis University

Előadó telefonszáma

+36308283714

Előadó e-mail címe

takacsistvanmarton@gmail.com

Az előadás címe

Novel Integrative Methods to Identify Therapeutic Targets and Compounds for Treating Kidney Fibrosis

Szerző(k) neve és munkahelye

István Márton Takács1, Domonkos Pap2, Zoltán Kiss2, Apor Veres-Székely1, Beáta Szebeni2, Csenge Pajtók1, Lili Jármi1, Balázs Ligeti3, Attila J. Szabó1,2, Ádám Vannay1,2
1. 1st Department of Paediatrics, Semmelweis University, Budapest, Hungary
2. MTA-SE, Paediatrics and Nephrology Research Group, Budapest, Hungary
3. Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary.

Szekció

Theoretical and Translational II. Posters

Language of the presentation

Hungarian

Section, first choice

Pharmaceutical Sciences

Section, second choice

Theoretical and Translational Medicine

Összefoglaló szövege

Aims: Chronic kidney diseases (CKD) characterised by renal fibrosis leading to gradual decline of renal function. Despite the urgent medical need there is still no effective therapy to inhibit or reverse the diseases. However, so far only a few therapeutic targets and compounds have been identified in the preclinical and clinical studies for the treatment of kidney fibrosis. Our aim was to develop an integrative framework to improve the identification possible target molecules and compounds which may have anti-fibrotic effects.

Methods: Comprehensive literature research was performed to identify those genes that have a role in renal fibrosis based on gene knockout (KO) animal studies. Moreover, genes of an extensive human microarray study that correlated with the severity of chronic kidney diseases were listed. Finally, the overlapping set of the two lists were generated and coupled with known compounds altering the function of the investigated genes in anti-fibrotic manner.

Results: Based on KO animal studies we found 91 pro-fibrotic and 73 anti-fibrotic genes which influenced the amount of extracellular matrix (ECM) depositions in the fibrotic kidney. Among them the expression of 54 gene were altered in the human kidney biopsies from patients with CKD as well. More than 300 compounds were identified that affecting these genes may exert anti-fibrotic effect.

Conclusion: We established an effective method to identify new drug targets and possible compounds that can be repurposed for the treatment of renal fibrosis.

Grants:
This Project was supported By the ÚNKP-18-4-SE-109 New National Excellence Program of the Ministry of Human Capacities and by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. OTKA K116928. FIKP

Additional Information

Supervisor: Ádám Vannay
E-mail address: vannay.adam@med.semmelweis-univ.hu

Bemutatás módja

Szóbeli

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4111

Start

13:05

End

13:08

Authors (legacy)

István Márton Takács1, Domonkos Pap2, Zoltán Kiss2, Apor Veres-Székely1, Beáta Szebeni2, Csenge Pajtók1, Lili Jármi1, Balázs Ligeti3, Attila J. Szabó1,2, Ádám Vannay1,2
1. 1st Department of Paediatrics, Semmelweis University, Budapest, Hungary
2. MTA-SE, Paediatrics and Nephrology Research Group, Budapest, Hungary
3. Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary.