PhD Scientific Days 2020

Clinical Medicine IV. Lectures

All Breast Milk Designed Equally?

Előadó neve

Dr. Vass, Réka

Előadó munkahelye

Department of Obstetrics and Gynecology, University of Pécs

Előadó telefonszáma

+36302532000

Előadó e-mail címe

rekaanna.vass@gmail.com

Az előadás címe

All Breast Milk Designed Equally?

Szerző(k) neve és munkahelye

Vass R.A.1,2, Kiss G.3, Takács T.1, Dombai F.1, Kiss A.A. 1, Miseta A.3, Ertl T.1,2
1 Department of Obstetrics and Gynecology, University of Pécs, Pécs, Hungary
2 MTA-PTE Human Reproduction Scientific Research Group
3 Department of Laboratory Medicine, University of Pécs, Pécs, Hungary

Szekció

Clinical Medicine IV. Lectures

Language of the presentation

Hungarian

Section, first choice

Clinical Medicine

Section, second choice

Theoretical and Translational Medicine

Összefoglaló szövege

Introduction: After birth breastfeeding is the only direct biological connection between the mother and newborn infant. Preterm birth disrupts intrauterine development, therefore preterm infants are deprived of transplacental hormonal exposure. Our investigation focused on the presence of pituitary hormones, like folliculus stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone (TSH), and thyroxin in breast milk during the first 6 month of lactation.
Methods: Mothers of term (n=15) and preterm (n=10) infants donated samples monthly from a midday breastfeeding during the first 6 months of lactation. Donors were recruited at the Department of Gynecology, University of Pécs, Hungary.
Results: Total protein levels (10.139±0.364 g/l vs 9.542±0.297 g/l; p=0.207) and TSH concentrations (0.018±0.001 vs 0.024±0.002 mU/l; p=0.096) were similar in the two groups. LH concentrations were significantly higher in the preterm samples (0.04±0.009 vs 0.015±0.004 U/l; p=0.041), respectively. In contrast, the FSH level was significantly higher in breast milk produced for term infants (0.179±0.014 vs 0.122±0.008 ng/ml; p=0.001). Thyroxin concentration was significantly higher in the preterm samples (0.671±0.061 vs 1.124±0.073 ng/ml; p<0.001). We did not detect significant monthly changes in the distribution of the investigated hormones during the study period.
Discussion: Breast milk contains hormones produced by the pituitary gland and thyroxin as well, and we detected the presence of these hormones in both groups during the examination period. Differences between the hormonal composition of term and preterm breast milk were found. The immature gastrointestinal tract and the reduced enzyme production may facilitate the absorption of these hormones or they may influence the development of the gastrointestinal tract directly.

Ethical Committee: PTE KK RIKEB 2018/7271.
Acknowledgements: We acknowledge the essential help of Katalin Szalaváry and Ágnes Rózsai. This work is supported by the grant GINOP 2.3.2-15-2016-00021 from the Economic Development and Innovation Operational Program and by the ÚNKP-19-3-I. This work is also supported by the New National Excellence Program of the Ministry for Innovation of the Government of Hungary.

Additional Information

Supervisor: Tibor Ertl
tibor.ertl@aok.pte.hu

Bemutatás módja

Szóbeli

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4757

Start

17:00

End

17:15

Authors (legacy)

Vass R.A.1,2, Kiss G.3, Takács T.1, Dombai F.1, Kiss A.A. 1, Miseta A.3, Ertl T.1,2
1 Department of Obstetrics and Gynecology, University of Pécs, Pécs, Hungary
2 MTA-PTE Human Reproduction Scientific Research Group
3 Department of Laboratory Medicine, University of Pécs, Pécs, Hungary