PhD Scientific Days 2020

Pharmaceutical Sciences I. Posters

Complex Morphological Characterization of Core-shell Fibers

Előadó neve

Dr. Kazsoki, Adrienn

Előadó munkahelye

University Pharmacy Department of Pharmacy Administration

Előadó telefonszáma

06302060093

Előadó e-mail címe

kazsoki.adrienn@pharma.semmelweis-univ.hu

Az előadás címe

Complex Morphological Characterization of Core-shell Fibers

Szerző(k) neve és munkahelye

Adrienn Kazsoki1, Attila Farkas2, Diána Balogh-Weiser2, Elena Mancuso3, Preetam K. Sharma3, Dimitrios A. Lamprou4, Romána Zelkó1

1University Pharmacy Department of Pharmacy Administration/ Semmelweis University, Hőgyes Endre utca 7-9, H-1092 Budapest, Hungary
2Department of Organic Chemistry and Technology/ Budapest University of Technology and Economics, Műegyetem rakpart 3, H-1111 Budapest, Hungary
3Nanotechnology and Integrated Bio-Engineering Centre (NIBEC)/ Ulster University, Jordanstown campus, UK
4School of Pharmacy/ Queen’s University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK

Szekció

Pharmaceutical Sciences I. Posters

Language of the presentation

Hungarian

Section, first choice

Pharmaceutical Sciences

Section, second choice

Molecular Sciences

Összefoglaló szövege

During the last decade, the formulation of nanofibrous materials loaded with different drugs for biomedical applications has evoked considerable interest. The core-shell fibers with their complex, unique structure can provide improved compatibility with target tissue and can further control of the drug release.
This study aimed to prepare polylactic acid (PLA) - poly(vinylpyrrolidone) (PVP) bicomponent core-shell fibrous sheets and examine the electrospinnability of the precursor combinations.
A full factorial experimental design (of two factors in three levels) was used to determine the best combination of the core (PLA)-and shell (PVP) viscous solutions for coaxial electrospinning. The morphology structure of the prepared sample was studied by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy.
The SEM photos showed that fibrous structures were obtained, without any beads and film-like areas in case of the preliminary study prepared with single-needle electrospinning and also in case of the coaxial electrospun samples. As the core and shell materials have different electron transmission abilities, the TEM method was suitable to detect the core-shell structure and their homogeneity as well. In the case of each composition, the desired structure was obtained with different homogeneity. The best sample was achieved with 15% (w/w) shell concentration combined with 8 % (w/w) PLA solution concentration. The XPS spectra of the nanofiber surfaces indicated that there is good interfacial stability between the inner and outer solution. Thus the developed coaxial electrospinning method with the examined solution concentration is an effective process for core-shell fiber formation. Raman spectroscopy also confirmed the core-shell structure and pointed out that amorphous solid dispersion was formed and homogenous drug distribution was obtained in the case of both samples.
Core-shell fibers of different compositions were successfully prepared. A novel Raman microspectrometry method was developed, which besides capable of verifying a core-shell structure, also can provide information of the drug distribution and the physical state of the active pharmaceutical ingredients incorporated to the polymer-based solid dispersions.

Additional Information

Supervisor: Romána Zelkó
E.mail address: zelko.romana@pharma.semmelweis-univ.hu

Bemutatás módja

Poszter

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1195

Start

11:25

End

11:28

Authors (legacy)

Adrienn Kazsoki1, Attila Farkas2, Diána Balogh-Weiser2, Elena Mancuso3, Preetam K. Sharma3, Dimitrios A. Lamprou4, Romána Zelkó1

1University Pharmacy Department of Pharmacy Administration/ Semmelweis University, Hőgyes Endre utca 7-9, H-1092 Budapest, Hungary
2Department of Organic Chemistry and Technology/ Budapest University of Technology and Economics, Műegyetem rakpart 3, H-1111 Budapest, Hungary
3Nanotechnology and Integrated Bio-Engineering Centre (NIBEC)/ Ulster University, Jordanstown campus, UK
4School of Pharmacy/ Queen’s University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK