PhD Scientific Days 2020

Clinical Medicine II. Lectures

Predictors and Characteristics of Coronary Artery Plaque Progression Using Serial CT Imaging

Előadó neve

Dr. Boussoussou, Melinda

Előadó munkahelye

Semmelweis University, Heart and Vascular Center

Előadó telefonszáma

06206632859

Előadó e-mail címe

melinda.b.md@gmail.com

Az előadás címe

Predictors and Characteristics of Coronary Artery Plaque Progression Using Serial CT Imaging

Szerző(k) neve és munkahelye

Dr. Melinda Boussoussou 1, Dr. Bálint Szilveszter 1, Dr. Márton Kolossváry 1, Dr. Borbála Vattay 1 , Dr. Judit Simon 1, Prof. Dr. Béla Merkely 1, Dr. Pál Maurovich-Horvat 1, 2

1 Heart and Vascular Center, Semmelweis University, Budapest
2 Medical Imaging Center, Semmelweis University, Budapest

Szekció

Clinical Medicine II. Lectures

Language of the presentation

Hungarian

Section, first choice

Clinical Medicine

Section, second choice

Health Sciences

Összefoglaló szövege

Introduction: The progression of coronary atherosclerosis is a dynamic process with significant changes in metabolism and morphology. Several studies have demonstrated that plaque progression can be seen as a prognostic factor of adverse events, regardless of the severity of the stenosis. In order to refine risk prediction better understanding of the predictors of plaque progression is of utmost importance.
Aims: Our study evaluates the extent of coronary artery disease (CAD) and the degree of the stenosis by serial coronary CT angiography (CCTA) with the aim to further elucidate the predictors of coronary plaque progression in patients with suspected CAD. 
Methods: In our retrospective study 115 patients were enrolled (mean age was 60.98±9.89; 74.5% male) who underwent serial CCTA. In order to analyze changes in plaque burden CCTA images were assessed by a single reader. Segment involvement score (SIS) and segment stenosis score (SSS) were assessed in 1577 segments. Using multivariate linear mixed models the effect of cardiovascular risk factors and statin therapy were also evaluated on SSS, SIS and the progression rate of coronary artery disease.
Results: In multivariate analysis age, male gender and statin therapy had direct effect on SSS. Regarding SIS, older age, male gender, diabetes mellitus and statin therapy were associated with higher scores. Annualized progression of SIS and SSS was increased by smoking: β=0.35 (CI:0.09-0.6, p=0.007) and β=0.20 (CI:0.04-0.37, p=0.017).
Conclusion: Our study results showed that CCTA accurately detects coronary plaque progression. SSS increased by gender, age and statin therapy, whilst total plaque burden was also associated with diabetes. Smoking is a significant factor of progression rate of coronary artery disease.

Additional Information

Bálint Szilveszter
szilveszter.balint@gmail.com

Bemutatás módja

Szóbeli

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4775

Start

12:05

End

12:20

Authors (legacy)

Dr. Melinda Boussoussou 1, Dr. Bálint Szilveszter 1, Dr. Márton Kolossváry 1, Dr. Borbála Vattay 1 , Dr. Judit Simon 1, Prof. Dr. Béla Merkely 1, Dr. Pál Maurovich-Horvat 1, 2

1 Heart and Vascular Center, Semmelweis University, Budapest
2 Medical Imaging Center, Semmelweis University, Budapest