PhD Scientific Days 2020

Clinical Medicine III. Posters

Cross Sectional Twin Study Shows Significant Heritability in the Background of Bone Mineral Density

Előadó neve

Dr. Piroska, Márton

Előadó munkahelye

Semmelweis University, Medical Imaging Centre

Előadó telefonszáma

+36205491303

Előadó e-mail címe

piroskamarton94@gmail.com

Az előadás címe

Cross Sectional Twin Study Shows Significant Heritability in the Background of Bone Mineral Density

Szerző(k) neve és munkahelye

Marton Piroska1, Zsofia Jokkel1, Helga Szabo1, Szilvia Meszaros3, Csaba Horvath3, David Laszlo Tarnoki1,2, Adam Domonkos Tarnoki1,2

1 Medical Imaging Centre, Semmelweis University, Budapest, Hungary
2 Hungarian Twin Registry, Budapest, Hungary
3 1st Department of Internal Medicine, Semmelweis University, Budapest, Hungary

Szekció

Clinical Medicine III. Posters

Language of the presentation

English

Section, first choice

Clinical Medicine

Section, second choice

Theoretical and Translational Medicine

Összefoglaló szövege

Purpose: Previous studies have demonstrated that risk of hip fracture is heritable. The aim of this study was to determine the genetic component of bone mineral density (BMD), using both X-ray and ultrasound assessment at multiple sites.

Methods and Materials: 160 adult, healthy Hungarian twins (97 monozygotic, MZ, 62 dizygotic, DZ; mean age 50.6±14.7 years), recruited from the Hungarian Twin Registry with no history of oncologic disease underwent cross sectional BMD studies in 2019. We measured X-ray BMD at multiple sites (lumbar spine, femur, hip and radius), whileas broadband ultrasound attenuation of the calcaneus was also determined. Heritability was calculated using univariate ACE model.

Results: Bone density had a strong genetic component at all sites with estimates of heritability ranging from 0.619 to 0.829. Lumbar and calcaneus BMD had major genetic components with estimates of 0.828 and 0.829 respectively, and least heritable (0.619) at femur. Broadband ultrasound attenuation at calcaneus had also a strong genetic component with an estimate of 0.816. No common environmental effect was found. The remaining variance was influenced by unique environment (0.171 to 0.381).

Conclusion: Bone mineral density is strongly heritable at all sights which may explain the importance of family history as a risk factor for bone fractures. Our results might stimulate further studies in family risk based osteoporosis screening.

Semmelweis University STIA fund was received for this work.

The local ethical committee approved the study (approval number: 189-4/2014). All participants gave informed consent.

Additional Information

Supervisor: Dr Tárnoki Ádám
E-mail address: tarnoki2@gmail.com

Bemutatás módja

Szóbeli

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4777

Start

12:43

End

12:46

Authors (legacy)

Marton Piroska1, Zsofia Jokkel1, Helga Szabo1, Szilvia Meszaros3, Csaba Horvath3, David Laszlo Tarnoki1,2, Adam Domonkos Tarnoki1,2

1 Medical Imaging Centre, Semmelweis University, Budapest, Hungary
2 Hungarian Twin Registry, Budapest, Hungary
3 1st Department of Internal Medicine, Semmelweis University, Budapest, Hungary