PhD Scientific Days 2020

Mental Sciences II. Lectures

Sleep Changes and Epileptiform Discharges in Parkinson’s and Alzheimer’s Disease: 24-hour EEG Study

Előadó neve

Dr. Papp, Anikó

Előadó munkahelye

National Institute of Clinical Neurosciences; School of PhD Studies, Mental Health Sciences, Semmelweis University, Budapest

Előadó telefonszáma

+367077778684

Előadó e-mail címe

papp.anik@gmail.com

Az előadás címe

Sleep Changes and Epileptiform Discharges in Parkinson’s and Alzheimer’s Disease: 24-hour EEG Study

Szerző(k) neve és munkahelye

1 Anikó Papp, National Institute of Clinical Neurosciences, Budapest; School of PhD Studies, Mental Health Sciences, Semmelweis University, Budapest
2 András Horváth, National Institute of Clinical Neurosciences, Budapest
3 Dániel Fabó, National Institute of Clinical Neurosciences, Budapest
4 Anita Kamondi, National Institute of Clinical Neurosciences, Budapest
5 Anna Szűcs, School of PhD Studies, Mental HEalth Sciences, Semmelweis University, Budapest

Szekció

Mental Sciences II. Lectures

Language of the presentation

Hungarian

Section, first choice

Mental Sciences

Section, second choice

Neurosciences

Összefoglaló szövege

Background: Sleep changes are common in neurodegenerative diseases but their pathophysiological significance is uncertain. The occurrence of epilepsy and epileptiform discharges is not known in Parkinson’s disease (PD), while increasing amount of data suggests that Alzheimer’s disease (AD) may be associated with higher risk of epileptic seizures.
Objective: We aimed to investigate the sleep structure, cognitive dysfunction, prevalence of epileptiform discharges and their relationship in PD and AD patients.
Methods: We included 25 PD (age:68,2+/-7,7y), 14 AD(age:68,5+/-9,2y) patients and 17 controls (C) (age:66,1+/-3,97y). All subjects underwent 24-hour EEG recording and neuropsychological tests. We analysed 8-hour recordings registered during the night. The sleep and EEG data were processed by Fercio’s EEG Plus and SystemPLUS EVOLUTION. SPSS Statistics was applied for statistical analysis.
Results: We found decreased total sleep time in PD and AD group (PDvsCp<0,001; ADvsC p<0,001), increased N1 stage of sleep in PD (PDvsC p=0,03), increased N2 stage in AD (ADvsC p= 0,042); decreased N3 stage in both PD and AD (PDvsC p<0,001, ADvsC p<0,001) and decreased REM sleep in PD (PDvsC p=0,003). Neuropsychology showed significant reduction in verbal fluency scores in the PD group (PDvsC p<0,001) particularly in semantic verbal fluency (SVF) (PDvsC p<0,001) and in all modalities in AD group. The frequency of epileptiform discharges was significantly higher in patients than in controls (80% in PD, 71% in AD, 23,5% in C; PDvsCp<0,001, ADvsC p=0,003). We found significantly lower semantic verbal fluency scores in the PD group having epileptiform discharges compared to PD patients with negative EEG (p= 0,010).
Conclusions: Since both AD and PD patients suffered from poor night sleep with loss of slow wave sleep and REM sleep reduction was specifically associated with PD, sleep characteristics might help in the differential diagnosis of various forms of neurocognitive disorders. More than half of our patients showed epileptiform discharges. The higher incidence of them in PD and the correlation with reduced performance in semantic verbal fluency may indicate the early involvement of temporal lobe in PD as well. Epileptiform discharges might have a negative effect on the cognitive function of dementia patients representing an important direction for further studies.

Additional Information

The presenter: Anikó Papp, papp.anik@gmail.com

Bemutatás módja

Szóbeli

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

2859

Start

11:55

End

12:10

Authors (legacy)

1 Anikó Papp, National Institute of Clinical Neurosciences, Budapest; School of PhD Studies, Mental Health Sciences, Semmelweis University, Budapest
2 András Horváth, National Institute of Clinical Neurosciences, Budapest
3 Dániel Fabó, National Institute of Clinical Neurosciences, Budapest
4 Anita Kamondi, National Institute of Clinical Neurosciences, Budapest
5 Anna Szűcs, School of PhD Studies, Mental HEalth Sciences, Semmelweis University, Budapest