PhD Scientific Days 2020

Pharmaceutical Sciences II. Posters

Implementation of Hot-melt Extrusion as a Tool for 3D Printing: Design and Evaluation of Baicalin-loaded Thermoplastic Filaments

Előadó neve

Dr. Géza, Jakab

Előadó munkahelye

Department of Pharmaceutics

Előadó telefonszáma

+3630/9937113

Előadó e-mail címe

jakab.geza@pharma.semmelweis-univ.hu

Az előadás címe

Implementation of Hot-melt Extrusion as a Tool for 3D Printing: Design and Evaluation of Baicalin-loaded Thermoplastic Filaments

Szerző(k) neve és munkahelye

Géza Jakab, István Antal
Semmelweis University, Department of Pharmaceutics

Szekció

Pharmaceutical Sciences II. Posters

Language of the presentation

Hungarian

Section, first choice

Pharmaceutical Sciences

Section, second choice

Theoretical and Translational Medicine

Összefoglaló szövege

Introduction: 3D printing is a process that creates a three-dimensional object layer-by-layer based on a 3D digital model. One of the most widely used 3D technology is fused deposition modelling (FDM), which utilizes a thermoplastic filament for the creation of different prototypes. Hot-melt extrusion (HME) is a process that can be applied for the production of filaments. The active molecule is blended with a thermoplastic polymer and then extruded as filaments that are used in 3D printing. Baicalin, the model drug used in this study, is a flavone glycoside, extracted from the root of Scutellaria baicalensis Georgi. It has numerous pharmacological effects (antioxidant, antimicrobial and anti-tumor), but the poor biopharmaceutical properties hamper its oral bioavailability. Furthermore, it has a thermolabile property.
Aims: The aim of this study was the development, analysis and preparation of baicalin-loaded filaments by hot-melt extrusion, which has suitable properties for 3D printing (flexibility, drug-loading, thermoplasticity, tensile strength). The focus was put on the evaluation of critical process-, and filament attributes. Other important goal was the characterization of crystalline-amorphous phase transition by powder x-ray diffraction.
Method: Preparation of drug-loaded filaments was carried out by hot-melt extrusion using different process parameters (temperature, rotation speed) and pharmaceutical excipients. Morphological characterization of filaments was fulfilled by digital microscopy using high-resolution imaging. The tool for the study of phase transitions was powder x-ray diffraction.
Results: PEG 6000 as thermoplastic polymer was successfully used for the creation of filaments. The optimized process parameter in case of HME was 60 °C and 3 rpm. From 1 g of powder approx. 50 cm of filament can be generated. The filament disintegrates in pH 1.2 dissolution medium within 15 minutes. Baicalin was added and blended with the polymer before extrusion and acceptable content uniformity was measured. Unfortunately, these kind of filaments were rigid and brittle. Therefore, triethyl citrate was added to the blend as a plasticizer, which gave filaments with suitable physical properties.
Conclusion: HME is a suitable method for the preparation of drug-loaded filaments. By optimizing the excipient system, 3D printed tablets can be generated.

Additional Information

István Antal
antal.istvan@pharma.semmelweis-univ.hu

Bemutatás módja

Poszter

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

2775

Start

12:55

End

12:58

Authors (legacy)

Géza Jakab, István Antal
Semmelweis University, Department of Pharmaceutics