PhD Scientific Days 2020

Health Sciences Lectures

Genetic Versus Environmental Link Between Obstructive Sleep Apnea and Lumbar Degeneration

Előadó neve

Dr. Szily, Marcell

Előadó munkahelye

Somogy Megyei Kaposi Mór Teahing Hospital Diagnostic Imaging Center

Előadó telefonszáma

+36303208156

Előadó e-mail címe

szilymarcell@hotmail.com

Az előadás címe

Genetic Versus Environmental Link Between Obstructive Sleep Apnea and Lumbar Degeneration

Szerző(k) neve és munkahelye

Szily Marcell1,2, Kovács Dániel T1, Forgó Bianka1, Márton Piroska1 , Eunae Kim3, Joohon Sung3, Pinheiro Marina4, Ferreira Paulo4, Kostyál László5, Oláh Csaba5, Kunos László6, Bikov András6, Tárnoki Ádám Domonkos1, Tárnoki Dávid László1
1 Medical Imaging Centre, Semmelweis University, Budapest, Hungary
2 Somogy Megyei Kaposi Mór Teaching Hospital Imaging Diagnostic Center
3 Complex Disease and Genome Epidemiology Branch, Department of Public Health Science, School of Public Health, Seoul National University, Seoul, Republic of Korea
4 The University of Sydney, Musculoskeletal Health, Faculty of Health Sciences, Discipline of Physiotherapy, Sydney, Australia
5 Borsod-Abaúj-Zemplén County and University Teaching Hospital, Department of Neurosurgery, Miskolc, Hungary
6 Department of Pulmonology, Semmelweis University, Budapest, Hungary

Szekció

Health Sciences Lectures

Language of the presentation

Hungarian

Section, first choice

Health Sciences

Section, second choice

Clinical Medicine

Összefoglaló szövege

IIntroduction: The lumbar degeneration often inflects lower back pain, one of the most inportant chronic pain syndrome and cause poor sleep quality and difficulties in falling asleep. Obstructive Sleep Apnea (OSA) is one of the most common sleep disorders and causes cognitive dysfunction, excessive daily sleepiness. Previous studies advocated a connection between poor sleep quality and low back pain (LBP), but no objective genetic study was conducted to understand the common pathway.
Methods: 71 Hungarian twin pairs involved from the Hungarian Twin Registry (42 monozygotic, MZ and 29 dizygotic, DZ pairs, mean age 51±16 years) underwent overnight polysomnography (Somnoscreen Plus Tele PSG, Somnomedics GMBH, Germany) and lumbar spine MRI (Siemens Magnetom Veria and Philips Ingenia 1.5T). The presence and number of disc bulging, Pfirmann score and total endplate score (TEPS) were recorded on T1 and T2 weighted MRI sequences and summarized. Apnea hypopnea index (AHI), respiratory disturbance index (RDI) and oxygen desaturation index (ODI) were registered. Daytime sleepiness was measured by Epworth Sleepiness Scale and LBP was assessed by a validated questionnaire. ACE model was applied, and negative binomial regression was used to assess the connection between OSA and disc degeneration.
Results: Prevalence of OSA and disc bulging was 39% and 68%. Parameters of sleep quality and sleepiness showed a substantial additive genetic background (AHI, ODI, RDI between 39% and 94%, p<0.05, Epworth scale: 27%, p<0.2). The lumbal annular high intensity was heritable and showed a strong link to ODI, contrarily to the disc bulging and the Epwort sleepiness scale which was determined by environmental factors. The lumbar disc bulging showed significant relationship with AHI and ODI in the binomial models (AHI: 0.06, p=0.021, ODI: 0.06, p<0.024, respectively). Disc bulging showed no genetic background, which suggested that the connection between disc bulging and OSA parameters are attributed to environmental factors.
Discussion and Conclusion: The link between the OSA and the disc degeneration is divisive. The disk bulging and OSA parameters showed a strong environmental relationship, whileas the lumbal anular high intensity and ODI was determined by genetic factors. Further research is stimulated to understand the therapeutic role of these results in OSA patients.

Additional Information

Financial support, grants: Hungarian Pulmonology Foundation (MPA, 2013), Erasmus+ scholarship.
Ethical Committee Approval: Semmelweis University TUKEB 189/2014.
Acknowledgement: Mónika Bánlaky.

Bemutatás módja

Szóbeli

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4779

Start

10:50

End

11:05

Authors (legacy)

Szily Marcell1,2, Kovács Dániel T1, Forgó Bianka1, Márton Piroska1 , Eunae Kim3, Joohon Sung3, Pinheiro Marina4, Ferreira Paulo4, Kostyál László5, Oláh Csaba5, Kunos László6, Bikov András6, Tárnoki Ádám Domonkos1, Tárnoki Dávid László1
1 Medical Imaging Centre, Semmelweis University, Budapest, Hungary
2 Somogy Megyei Kaposi Mór Teaching Hospital Imaging Diagnostic Center
3 Complex Disease and Genome Epidemiology Branch, Department of Public Health Science, School of Public Health, Seoul National University, Seoul, Republic of Korea
4 The University of Sydney, Musculoskeletal Health, Faculty of Health Sciences, Discipline of Physiotherapy, Sydney, Australia
5 Borsod-Abaúj-Zemplén County and University Teaching Hospital, Department of Neurosurgery, Miskolc, Hungary
6 Department of Pulmonology, Semmelweis University, Budapest, Hungary