PhD Scientific Days 2020

Clinical Medicine IV. Lectures

Genetic versus Environmental Background on the Relationship of Telomere Length and Bone Mineral Density

Előadó neve

Dr. Jokkel, Zsofia

Előadó munkahelye

Medical Imaging Centre, Semmelweis University

Előadó telefonszáma

06306602336

Előadó e-mail címe

zsofijokkel@gmail.com

Az előadás címe

Genetic versus Environmental Background on the Relationship of Telomere Length and Bone Mineral Density

Szerző(k) neve és munkahelye

Zsofia Jokkel1, Dora Melicher2,3,4, Anett Illes5, Marton Piroska1, Andras Bikov6, Helga Szabo1, Anita Hernyes1, Maria Judit Molnar5, Edit Iren Buzas2,3, Andras Falus2, Szilvia Meszaros7, Csaba Horvath7, Adam Domonkos Tarnoki1, David Laszlo Tarnoki1
1 Medical Imaging Centre, Semmelweis University, Budapest, Hungary.
2 Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
3 MTA-SE Immunproteogenomics Extracellular Vesicle Research Group, Budapest, Hungary.
4 Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
5 Institute of Genomic Medicine and Rare Disorders, Semmelweis University, Budapest, Hungary.
6 Department of Pulmonology, Semmelweis University, Budapest, Hungary.
7 1st Department of Internal Medicine, Semmelweis University, Budapest, Hungary.

Szekció

Clinical Medicine IV. Lectures

Language of the presentation

English

Section, first choice

Clinical Medicine

Section, second choice

Theoretical and Translational Medicine

Összefoglaló szövege

Introduction. Environmental and genetical factors determine the development of diseases, although the amount of impact made by these components may vary significantly in different disorders. Telomere length (TL), as a hallmark of cellular aging, may be involved in the development of several diseases associated with aging by modulating oxidative stress. Bone mineral density (BMD) is an indicator of osteoporosis that has been associated with oxidative stress suggesting a possible connection with TL.
Aims. To investigate the genetic and environmental influences on telomere length and to examine the possible relationship with BMD in a twin study.
Method. 56 twin pairs (37 monozygotic and 19 dizygotic pairs, 63% female, mean age: 51.8±14.1 ys) underwent central (lumbal spine L1-L4, femoral neck and hip) and peripheral (radius) bone DEXA scans (Hologic Horizon WI, Hologic Sahara) and blood test. TL was measured from peripheral blood samples by calculating the number of telomere repeats compared to a single-copy gene (albumin) using qPCR. ACE model was used to decompose the variance into additive genetic, common and unique environmental factors and log-linear regression was used between TL and BMD.
Results. The estimate correlations in monozygotic (0.796, confidence interval [CI] 0.686 to 0.871) and dizygotic (0.770, CI 0.576 to 0.881) pairs indicated no additive genetic effect on TL. In the CE model, the impact of shared environmental factors explained 78% (95% CI, 69% to 85%), while the unique environmental factors explained 22% (95% CI, 15% to 31%) of the variance in TL. In the regression test we found significant linear relationship between the logarithm of TL and mineral density of bones (estimate: 0.091, p<0.05, R^2: 0.115), which combined with the results of the ACE model, are attributed to environmental factors.
Conclusion. In our study TL was mainly influenced by environmental factors. Our results showed a non-genetic relationship between TL and BMD suggesting a possible link between oxidative stress and osteoporosis. Our preliminary study might stimulate further investigations to specifically target the possible link between TL and osteoporosis markers, with the aim to develop additional early predictive markers for osteoporosis.

Additional Information

Adam Domonkos Tarnoki
tarnoki2@gmail.com

Bemutatás módja

Szóbeli

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4780

Start

17:45

End

18:00

Authors (legacy)

Zsofia Jokkel1, Dora Melicher2,3,4, Anett Illes5, Marton Piroska1, Andras Bikov6, Helga Szabo1, Anita Hernyes1, Maria Judit Molnar5, Edit Iren Buzas2,3, Andras Falus2, Szilvia Meszaros7, Csaba Horvath7, Adam Domonkos Tarnoki1, David Laszlo Tarnoki1
1 Medical Imaging Centre, Semmelweis University, Budapest, Hungary.
2 Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
3 MTA-SE Immunproteogenomics Extracellular Vesicle Research Group, Budapest, Hungary.
4 Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
5 Institute of Genomic Medicine and Rare Disorders, Semmelweis University, Budapest, Hungary.
6 Department of Pulmonology, Semmelweis University, Budapest, Hungary.
7 1st Department of Internal Medicine, Semmelweis University, Budapest, Hungary.