PhD Scientific Days 2020

Theoretical and Translational III. Posters

Mechanisms of Cerebrovascular Autoregulatory Adaptation to Preeclampsia - Review of the Literature

Előadó neve

Dr. Kantor, Mark

Előadó munkahelye

Department of Translational Medicine, Semmelweis University

Előadó telefonszáma

+36205956054

Előadó e-mail címe

kantormark1995@gmail.com

Az előadás címe

Mechanisms of Cerebrovascular Autoregulatory Adaptation to Preeclampsia - Review of the Literature

Szerző(k) neve és munkahelye

Mark Kantor1,2,3,4, Zsolt Szedlacsek2, Zsolt Herfert2, Adam Lelbach1,2,3,4,5, Akos Koller1,3,4

1Department of Translational Medicine and 2Departmental Group of Geriatrics,
2nd Department of Internal Medicine, Faculty of Medicine,
3Department of Morphology and Physiology, Faculty of Health Sciences,
Semmelweis University, Budapest, Hungary
4Research Center for Sport Physiology, Institute for Sports and Health Science,
University of Physical Education, Budapest, Hungary
5Dr. Rose Private Hospital, Budapest, Hungary

Szekció

Theoretical and Translational III. Posters

Language of the presentation

English

Section, first choice

Theoretical and Translational Medicine

Section, second choice

Clinical Medicine

Összefoglaló szövege

Aim: Preeclampsia is a serious disease, complicating 2%-8% of pregnancies and imposing great hemodynamic load on the cerebral circulation of the mother, but it is very dangerous for fetus, as well (Chen, 2014). A constant blood flow to the brain is provided by cerebrovascular autoregulation - within wide range of systemic blood pressure (Jeyabalan, 2013). Impairment of this regulation can have serious consequences on the brain.
Method: The available literature (PubMed) has been reviewed and critically analyzed regarding the importance of cerebrovascular vasomotor responses and the efficacy of cerebral autoregulation in preeclampsia.
Results: According to the international research results, in preeclampsia there are more frequent strokes and cerebral events (Chandra, 2017). The placental ischemia/hypoxia is one of the initiatory mechanisms of preeclampsia, which induces oxidative stress, immunological dysfunction and imbalance between pro- and anti-angiogenic factors (Hod, 2015). It has been demonstrated by animal studies, that placental insufficiency is an important step in the manifestation of preeclampsia (Granger, 2006). Through maternal vascular endothelial dysfunction, placental insufficiency leads to the reduction of vasoactive mediators (changes of the arachidonic acid mechanism) and increased generation of vasoconstrictor molecules, thus reduce the blood supply to multiple organs (Gilbert, 2008). Studies have shown, that myogenic responses of middle cerebral artery importantly involved in the autoregulation are impaired in preeclampsia (Ryan, 2011).
Conclusion: The main mechanisms regulating the diameter of the small cerebral arteries are the pressure- and flow-induced diameter changes, which provide constant cerebral blood flow, however further studies are needed to characterize the myogenic response and the flow mediated constriction in brain vessels during preeclampsia. Through the identification and pharmacological modulation of the arachidonic acid related signalling pathways better prevention and treatment can be developed for hypertension during pregnancy.
Akos Koller akos.koller@gmail.com
Adam Lelbach adam.lelbach@gmail.com

Additional Information

Support: Scientific Excellence Program at the University of Physical Education, Innovation and Technology Ministry, Hungary, 2019. Higher Education Institutional Excellence Program at Semmelweis University and the National Bionika Program ED_17-1-2017-0009, Hungary. Grant from the Hungarian Hypertension Society 2019. Doctoral School of the Semmelweis University 2019.

Bemutatás módja

Poszter

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4787

Start

11:19

End

11:22

Authors (legacy)

Mark Kantor1,2,3,4, Zsolt Szedlacsek2, Zsolt Herfert2, Adam Lelbach1,2,3,4,5, Akos Koller1,3,4

1Department of Translational Medicine and 2Departmental Group of Geriatrics,
2nd Department of Internal Medicine, Faculty of Medicine,
3Department of Morphology and Physiology, Faculty of Health Sciences,
Semmelweis University, Budapest, Hungary
4Research Center for Sport Physiology, Institute for Sports and Health Science,
University of Physical Education, Budapest, Hungary
5Dr. Rose Private Hospital, Budapest, Hungary