PhD Scientific Days 2020

Clinical Medicine III. Posters

Examination of Possible Causes of Ineffective Radiosynoviorthesis

Előadó neve

Dr. Viktória, Nagy

Előadó munkahelye

Országos Reumatológiai és Fizioterápiás Intézet

Előadó telefonszáma

06702221715

Előadó e-mail címe

nviktoria1120@gmail.com

Az előadás címe

Examination of Possible Causes of Ineffective Radiosynoviorthesis

Szerző(k) neve és munkahelye

Nagy Viktória, Poór Gyula, Hangody László, Szerb Imre

1 Országos Reumatológiai és Fizioterápiás Intézet, Budapest
2 Országos Reumatológiai és Fizioterápiás Intézet, Budapest
3 Uzsoki Utcai Kórház, Ortopéd-Traumatológiai Osztály / Semmelweis Egyetem Traumatológiai Tanszék, Budapest
4 Uzsoki Utcai Kórház, Ortopéd-Traumatológiai Osztály / Semmelweis Egyetem Traumatológiai Tanszék, Budapest

Szekció

Clinical Medicine III. Posters

Language of the presentation

Hungarian

Section, first choice

Clinical Medicine

Section, second choice

Clinical Medicine

Összefoglaló szövege

Introduction: Synovitis is the inflammation of the synovial membrane which can develop due to various causes. It is usually associated with pain and swelling of the joint. This is followed by the production of inflammatory cytokines as the synovial membrane attaches to the joint surface causing cartilage damage, leading to pain, reduced range of motion, and osteoarthritis in the long-term. For these reasons, it is important to treat the synovitis. Radiosynoviorthesis is suitable for eliminating synovitis in the treated joints with a 73%±17% success rate according to the international literature.
Aims: 773 radiosynoviortheses were performed at the Orthopaedic-Trauma Department of Uzsoki Hospital since 2003. The follow-up examinations proved 81% success rate. The goal of our study was to analyse the possible reasons of ineffective proce¬dures. We assumed that the cause of ineffectiveness is that the injected colloid wasn’t phagocytised by „A“ type macrophages and that synovitis is still persisted.
Patients and methods: We performed 38 arthroscopic synovectomies in different joints (4 hips, 28 knees and 6 ankles) in 38 patients an average 10 month (7-16) after the ineffective radiosynoviortheses. According to the therapeutic protocol this procedure was the second step. There were 25 female and 13 male patients. The average age was 52 years (26-64). Histological and electronmicroscopic examinations were carried out on 76 segments from the surgically removed synovial membranes. The electronmicroscopic examinations were performed in the Institute of Experimental Medicine of the Hungarian Academy of Sciences. The histological examinations were performed at the Pathology Department of Uzsoki Hospital.
Results: The histological examinations revealed that, all of the synovial samples were inflamed, meaning that synovitis is still persisted in all of the treated joints after ineffective radiosynoviorthesis. In case of the electronmicroscopic examinations we couldn’t detect stable isotope in the lysosomes of „A“ type macrophages.
Conclusion: Radiosynoviorthesis can be a good alternative in the treatment of synovitis. In case of ineffective procedures synovitis persisted. We concluded that the main cause of ineffectiveness is that the macrophages didn’t phagocytise the injected isotope.

Additional Information

Supervisor: Imre Szerb
E-mail address: szerbimre@gmail.com

Bemutatás módja

Poszter

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4791

Start

12:40

End

12:43

Authors (legacy)

Nagy Viktória, Poór Gyula, Hangody László, Szerb Imre

1 Országos Reumatológiai és Fizioterápiás Intézet, Budapest
2 Országos Reumatológiai és Fizioterápiás Intézet, Budapest
3 Uzsoki Utcai Kórház, Ortopéd-Traumatológiai Osztály / Semmelweis Egyetem Traumatológiai Tanszék, Budapest
4 Uzsoki Utcai Kórház, Ortopéd-Traumatológiai Osztály / Semmelweis Egyetem Traumatológiai Tanszék, Budapest