PhD Scientific Days 2020

Theoretical and Translational IV. Lectures

Characterization of the Mechanisms Leading to Age-related Changes of Meningeal Lymphatics

Előadó neve

Dr. Ocskay, Zsombor

Előadó munkahelye

Department of Physiology, Semmelweis University School of Medicine, Budapest, Hungary

Előadó telefonszáma

0036205802280

Előadó e-mail címe

ocskay.zsombor@med.semmelweis-univ.hu

Az előadás címe

Characterization of the Mechanisms Leading to Age-related Changes of Meningeal Lymphatics

Szerző(k) neve és munkahelye

Zsombor Ocskay1,2, László Balint1,2, Zoltán Jakus1,2
1Department of Physiology, Semmelweis University School of Medicine, Budapest, Hungary
2MTA-SE "Lendület" Lymphatic Physiology Research Group of the Hungarian Academy of Sciences and the Semmelweis University

Szekció

Theoretical and Translational IV. Lectures

Language of the presentation

English

Section, first choice

Molecular Sciences

Section, second choice

Theoretical and Translational Medicine

Összefoglaló szövege

Background:
Recent studies have described the presence of the meningeal lymphatic vessels in the dura mater, and suggested their role in Alzheimer’s disease and multiple sclerosis. In our former study we described that lymph flow induces the postnatal maturation of the meningeal lymphatic structures. It has also been suggested that the VEGFR3 signaling plays an important role in the development and maintenance of meningeal lymphatic vessels.

Objectives:
We aimed at characterizing the age-related structural changes of the meningeal lymphatics and investigating the role of lymphangiogenic factors in the development and maintenance of the meningeal lymphatics.

Materials and methods:
For characterization of the meningeal lymphatic structures, lymphatic endothelial cell-specific immunostainings were used in wild-type mice and mice with lymphangiogenic factor deficiency at different ages including young and old animals. Lymphatic function was monitored by injection of labeled macromolecules into the CNS followed by assessment of uptake and drainage to the cervical lymph nodes.

Results:
We have characterized the structural changes in the meningeal lymphatic structures in young animals and during aging. Our results showed that the structural integrity and density of meningeal lymphatic vessels gradually decrease over time. Moreover, lymphangiogenic factor deletion impaired the postnatal development of the meningeal lymphatics, and enhanced the degradation of the meningeal lymphatic structures in aged mice.

Conclusions:
We revealed that a structural degradation of the meningeal lymphatics occurs during aging. Our results also indicate the importance of lymphangiogenic mechanisms not only in the development, but also in the prevention of the age-related degradation of meningeal lymphatics. The degradation of meningeal lymphatic structures in aging may play an important role in the pathophysiology of Alzheimer's disease.

Additional Information

Zoltán Jakus
jakus.zoltan@med.semmelweis-univ.hu

Bemutatás módja

Szóbeli

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4805

Start

11:55

End

12:10

Authors (legacy)

Zsombor Ocskay1,2, László Balint1,2, Zoltán Jakus1,2
1Department of Physiology, Semmelweis University School of Medicine, Budapest, Hungary
2MTA-SE "Lendület" Lymphatic Physiology Research Group of the Hungarian Academy of Sciences and the Semmelweis University