PhD Scientific Days 2020

Clinical Medicine III. Posters

Position of Macula Lutea and Presence of Proliferative Vitreoretinopathy Affect Intravitreal Cytokine Expression in Rhegmatogenous Retinal Detachment

Előadó neve

Dr. Balogh, Anikó

Előadó munkahelye

Department of Ophthalmology, Semmelweis University, Budapest, Hungary

Előadó e-mail címe

aniko90127@gmail.com

Az előadás címe

Position of Macula Lutea and Presence of Proliferative Vitreoretinopathy Affect Intravitreal Cytokine Expression in Rhegmatogenous Retinal Detachment

Szerző(k) neve és munkahelye

Anikó Balogh1,2, Tibor Milibák2, Viktória Szabó1, Zoltán Zsolt Nagy1, Miklós D Resch1
1 Department of Ophthalmology, Semmelweis University, Budapest, Hungary
2 Department of Ophthalmology, Uzsoki Hospital Budapest, Hungary

Szekció

Clinical Medicine III. Posters

Language of the presentation

Hungarian

Section, first choice

Clinical Medicine

Section, second choice

Molecular Sciences

Összefoglaló szövege

Introduction: Our purpose was to evaluate the concentrations of intravitreal cytokines in patients with rhegmatogenous retinal detachment (RRD). We hypothesized that patients with macula on RRD have lower levels of cytokines compared to patients with macula off RRD and proliferative vitreoretinopathy (PVR).
Methods: Vitreous fluids were collected during 23G pars plana vitrectomy from 58 eyes of 58 patients. Indication for vitrectomy included macula off and macula on RRD, PVR, and idiopathic epiretinal membrane (ERM). A multiplex chemiluminescent immunoassay was performed to measure the concentrations of 48 cytokines, chemokines, and growth factors.
Results: Levels of HGF, IL-6, IL-8, IL-16, IFN-gamma, MCP-1, and MIF were significantly higher in all groups of retinal detachment compared to ERM. Levels of CTACK, eotaxin, G-CSF, IP-10, MIG, SCF, SCGF-beta, SDF-1alpha were significantly higher in PVR compared to macula on RRD and ERM. Levels of IL-1ra, IL-5, IL-9, M-CSF, MIP-1alpha, and TRIAL were significantly higher in PVR compared to macula on RRD.
Conclusions: Our results indicate that the position of macula lutea and the presence of PVR significantly influence the intravitreal cytokine expression. The detected proteins may serve as biomarkers to estimate the possibility of PVR formation and may help to invent personalized therapeutic strategies to slow down or prevent PVR.
Additional information:
„SUPPORTED BY THE ÚNKP-19-3-I NEW NATIONAL EXCELLENCE PROGRAM OF THE MINISTRY FOR INNOVATION AND TECHNOLOGY.”

Bemutatás módja

Poszter

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

5133

Start

12:25

End

12:28

Authors (legacy)

Anikó Balogh1,2, Tibor Milibák2, Viktória Szabó1, Zoltán Zsolt Nagy1, Miklós D Resch1
1 Department of Ophthalmology, Semmelweis University, Budapest, Hungary
2 Department of Ophthalmology, Uzsoki Hospital Budapest, Hungary