PhD Scientific Days 2021

MO_I_L: Molecular Sciences I. Lectures

Modular Reorganization of Signaling Networks during the Development of Cancer

Előadó neve

Dr. Kovács, Borbála

Előadó munkahelye

Semmelweis University

Előadó telefonszáma

+36202506473

Előadó e-mail címe

kovacsborbala5@gmail.com

Az előadás címe

Modular Reorganization of Signaling Networks during the Development of Cancer

Szerző(k) neve és munkahelye

Semmelweis University Department of Molecular Biology, Budapest

Bemutatás módja

Szóbeli

Szekció

Molecular Sciences I. Lectures

Language of the presentation

English

Preferred session

Molecular Sciences

Összefoglaló szövege

Network science is an emerging tool in systems biology and oncology, providing novel, system-level insight into the development of cancer. Studying signaling networks in the process of oncogenesis enlight the adaptive mechanisms taking part in the cancerous transformation of healthy cells. For this purpose, colon cancer proved to be an excellent candidate as the preliminary phase, and adenoma has a long evolution time. Transcriptomic data have been collected from normal colon, colon adenoma, and colon cancer samples for calculating link (i.e., network edge) weights as approximative proxies for protein abundances, and link weights were included in the Human Cancer Signaling Network. We found that the adenoma phase clearly differs from the normal and cancer states in terms of a more scattered link weight distribution and enlarged network diameter. Modular analysis shows the rearrangement of the apoptosis- and the cell-cycle-related modules, whose pathway enrichment analysis supports the relevance of targeted therapy. Our work enriches the system-wide assessment of cancer development, showing specific changes for the adenoma state.

University and Doctoral School

Semmelweis University, Doctoral School of Molecular Medicine

Supervisor

Prof. Péter Csermely

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4707

Start

10:00

End

10:15

Authors (legacy)

Semmelweis University Department of Molecular Biology, Budapest