PhD Scientific Days 2021

TT_I_P: Theoretical and Translational Medicine I. Posters

Animal models of preeclampsia for investigating cerebrovascular autoregulation – advantages and limitations

Előadó neve

Dr. Kantor, Mark

Előadó munkahelye

Institute of Translational Medicine, Semmelweis University

Előadó telefonszáma

+36205956054

Előadó e-mail címe

kantormark1995@gmail.com

Az előadás címe

Animal models of preeclampsia for investigating cerebrovascular autoregulation – advantages and limitations

Szerző(k) neve és munkahelye

Mark Kantor1, Adam Lelbach 2,3,4, Akos Koller1,4

1Institute of Translational Medicine and 2Departmental Group of Geriatrics, Department of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, Budapest
3Dr. Rose Private Hospital, Budapest
4Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University, Budapest

Bemutatás módja

Poszter

Szekció

Theoretical and Translational Medicine I. Posters

Language of the presentation

English

Preferred session

Theoretical and Translational Medicine

Összefoglaló szövege

Introduction: Preeclampsia is a leading cause of both maternal and fetal morbidity and mortality, affecting ~8% of pregnancies. Despite of extensive research, the underlying mechanisms are still unclear. Many animal models have been developed, which share many of the features, but do not include the complete symptoms present in this human disease. One of the less addressed issue in preeclampsia is the effects of increased systemic blood pressure on the autoregulation of cerebral blood flow.
Aims: Thus, we aimed to elucidate whether the available animal models are suitable to study the adaptation of cerebral autoregulation in preeclampsia.
Methods: We have reviewed the literature (PUBMED) regarding the animal models of preeclampsia.
Results: In general, animal models of preeclampsia can be divided into 4 groups: 1) spontaneous, 2) surgically induced, 3) pharmacologically induced and 4) transgenic. Model 1: the Dahl salt-sensitive rat is a genetic model of kidney disease and hypertension. Model 2: the reduced uterine perfusion pressure (RUPP) rat elicited with a combination of aortic constriction and occlusion of the uterine-ovarian arteries. Model 3: inhibition of nitric oxide synthase in rats by L-NAME at different gestational stages, which leads to preeclampsia-like symptoms. Model 4: overexpression of the VEGF antagonist sFlt-1 via the administration of viral vectors results in pregnancy-specific proteinuria and hypertension in rats.
Conclusion: Preeclampsia is a disease unique to humans. Although several animal models exist and some of them have placental lesions, none of them is presenting the complexity of human disease, thus extrapolation of the findings to human preeclampsia must be made with caution. Importantly, the effects of high systemic blood pressure on the mechanosensitive mechanisms contributing to the adaptation of cerebral autoregulation providing protection against stroke – which can occur in preeclampsia - have not yet been addressed. Therefore, at first, comparison of cerebrovascular adaptation should be studied in young and old pregnant rats, which would help to elucidate the effects and underlying mechanisms of cerebrovascular adaptations in preeclampsia.
Funding: OTKA132596, K_19; EFOP-3.6.3-VEKOP-16-2017-00009, Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése.

University and Doctoral School

Semmelweis University, Doctoral School of Theoretical and Translational Medicine

Supervisor

Prof. Akos Koller

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

4787

Start

10:39

End

10:42

Authors (legacy)

Mark Kantor1, Adam Lelbach 2,3,4, Akos Koller1,4

1Institute of Translational Medicine and 2Departmental Group of Geriatrics, Department of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, Budapest
3Dr. Rose Private Hospital, Budapest
4Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University, Budapest