PhD Scientific Days 2021

CL_II_P: Clinical Medicine II. Posters

Diagnostic and Prognostic Significance of Cardiac Magnetic Resonance-based Strain Analysis in Hypertrophic Cardiomyopathy

Előadó neve

Dr. Dohy, Zsófia

Előadó munkahelye

Heart and Vascular Center of Semmelweis University

Előadó telefonszáma

20/6701228

Előadó e-mail címe

dohyzsofi@gmail.com

Az előadás címe

Diagnostic and Prognostic Significance of Cardiac Magnetic Resonance-based Strain Analysis in Hypertrophic Cardiomyopathy

Szerző(k) neve és munkahelye

Zsófia Dohy1, Liliána Szabó1, Attila Tóth1, Csilla Czimbalmos1, Ferenc Imre Suhai1, László Gellér1, Béla Merkely1, Hajnalka Vágó1

1 Heart and Vascular Center of Semmelweis University, Budapest

Bemutatás módja

Poszter

Szekció

Clinical Medicine II. Posters

Language of the presentation

Hungarian

Preferred session

Clinical Medicine

Összefoglaló szövege

Introduction: The prognosis of patients with hypertrophic cardiomyopathy (HCM) varies greatly. Cardiac magnetic resonance (CMR) is the gold standard method for assessing left ventricular (LV) mass and volumes. Myocardial fibrosis can be noninvasively detected using CMR. Moreover, feature-tracking (FT) strain analysis provides information about LV deformation.
Aims: We aimed to investigate the strain characteristics, and the prognostic significance of CMR parameters in HCM patients.
Methods: We investigated 187 HCM patients (50±19 years) and 45 healthy controls (44±8 years). LV volumes, mass (LVM), ejection fraction, global LV longitudinal (GLS), circumferential (GCS) and radial (GRS) strain parameters and mechanical dispersion (MD) were calculated. Myocardial fibrosis was quantified. The combined endpoint of our study was all-cause mortality, heart transplantation, malignant ventricular arrhythmias and appropriate implantable cardioverter defibrillator (ICD) therapy. The arrhythmia endpoint was malignant ventricular arrhythmias and appropriate ICD therapy.
Results: HCM patients had in absolute value higher GRS (86±31 vs. 67±15%) and GCS (-41±9 vs. -36±6%) and higher longitudinal MD (MDL) (17±5 vs. 14±8%) compared to the controls (p<0.001). More pronounced LV hypertrophy was associated with impaired GLS (r=0.28, p<0.0001) and increased MDL (r=0.25, p<0.001). More extended myocardial fibrosis correlated with impaired GLS (r= 0.27, p<0.001). The LVM index (LVMi) was an independent CMR predictor of the combined endpoint (p<0.01). The univariate predictors of the combined endpoint were LVMi, GLS, GRS and MDL. The univariate predictors of arrhythmia events included LVMi and myocardial fibrosis.
Conclusion: LVMi was an independent CMR predictor of major events, and myocardial fibrosis predicted arrhythmia events in HCM patients. Strain analysis provided additional information for risk stratification in HCM patients.
Funding: EFOP-3.6.3-VEKOP-16-2017-00009, Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése

University and Doctoral School

Semmelweis University, Doctoral School of Theoretical and Translational Medicine

Supervisor

Hajnalka Vágó, MD, PhD

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

2745

Start

13:02

End

13:05

Authors (legacy)

Zsófia Dohy1, Liliána Szabó1, Attila Tóth1, Csilla Czimbalmos1, Ferenc Imre Suhai1, László Gellér1, Béla Merkely1, Hajnalka Vágó1

1 Heart and Vascular Center of Semmelweis University, Budapest