PhD Scientific Days 2021

CL_I_L: Clinical Medicine I. Lectures

What do we know about ARNI based on clinical experience?- Use of ENTRESTO in everyday clinical practice

Előadó neve

Dr. Kuthi, Luca

Előadó munkahelye

Semmelweis University Heart and Vascular Center

Előadó telefonszáma

06302875885

Előadó e-mail címe

lucakuthi.cvc@gmail.com

Az előadás címe

What do we know about ARNI based on clinical experience?- Use of ENTRESTO in everyday clinical practice

Szerző(k) neve és munkahelye

1. Luca Katalin Kuthi, Semmelweis University Heart and Vascular Center, Budapest, Hungary
2. Eperke Dóra Merkel, Semmelweis University Heart and Vascular Center, Budapest, Hungary
3. Annamária Kosztin, Semmelweis University Heart and Vascular Center, Budapest, Hungary
4.Boglárka Veres, Semmelweis University Heart and Vascular Center, Budapest, Hungary
5.Anett Behon, Semmelweis University Heart and Vascular Center, Budapest, Hungary
6.Walter Richárd Schwertner, Semmelweis University Heart and Vascular Center, Budapest, Hungary
7. Béla Merkely, Semmelweis University Heart and Vascular Center, Budapest, Hungary

Bemutatás módja

Szóbeli

Szekció

Clinical Medicine I. Lectures

Language of the presentation

Hungarian

Preferred session

Clinical Medicine

Összefoglaló szövege

Introduction: PARADIGM-HF trial demonstrated superiority of sacubitril/valsartan over enalapril in patients with heart failure with reduced ejection fraction (HFrEF). However, patients in clinical practice may differ in their characteristics and overall risk compared with patients in clinical trials, and additional outcomes can be observed in real world.
Aims: Our aim was to evaluate the effectiveness, tolerance and safety after six-months follow-up of Hungarian patients with stable chronic HFrEF treated with sacubitril/valsartan.
Methods: We enrolled 250 HFrEF patients (aged 66 years, 89% males) in NYHA class II–IV. Clinical, laboratory and echocardiographic parameters were evaluated at baseline and at 3 and 6 months.
Results: At baseline the median ejection fraction (EF) was 28%, the median NT-proBNP level was 2673 pg/ml, the median eGFR level was 61.1 and the average potassium level was 4.6 mmol/l. The EF showed significant improvement at 6 month follow-up. The NT-proBNP level showed also showed significant improvement at 6 month FU. The eGFR and potassium levels didn’t change significantly. The average follow-up was 247 days. 25 patients (10%) died, and 7 patients underwent heart transplantation or ventricle assist device implantation. 26 patient reached the maximum dosage. The treatment has to be stopped in 8 cases (3%).
Conclusion: Efficacy of sacubitril/valsartan in terms of both mortality and hospitalization, symptoms and quality of life is significantly better than ACE inhibitors. It is safe to use and has a better side effect profile than ACE inhibitors. In proper patient selection, NT-proBNP levels plays a key role and should be measured as part of heart failure care.

University and Doctoral School

Semmelweis University, Doctoral School of Theoretical and Translational Medicine

Supervisor

Dr. Annamária Kosztin- Dr. Béla Merkely

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

6063

Start

10:00

End

10:15

Authors (legacy)

1. Luca Katalin Kuthi, Semmelweis University Heart and Vascular Center, Budapest, Hungary
2. Eperke Dóra Merkel, Semmelweis University Heart and Vascular Center, Budapest, Hungary
3. Annamária Kosztin, Semmelweis University Heart and Vascular Center, Budapest, Hungary
4.Boglárka Veres, Semmelweis University Heart and Vascular Center, Budapest, Hungary
5.Anett Behon, Semmelweis University Heart and Vascular Center, Budapest, Hungary
6.Walter Richárd Schwertner, Semmelweis University Heart and Vascular Center, Budapest, Hungary
7. Béla Merkely, Semmelweis University Heart and Vascular Center, Budapest, Hungary