PhD Scientific Days 2021

TT_I_P: Theoretical and Translational Medicine I. Posters

Myocardial work index: a marker of left ventricular contractility in pressure- or volume overload-induced heart failure

Előadó neve

Dr. Ruppert, Mihály

Előadó munkahelye

Heart and Vascular Center, Semmelweis University, Városmajor St. 68, Budapest, H-1122, Hungary

Előadó telefonszáma

+36206701233

Előadó e-mail címe

ruppertmis@gmail.com

Az előadás címe

Myocardial work index: a marker of left ventricular contractility in pressure- or volume overload-induced heart failure

Szerző(k) neve és munkahelye

Mihály Ruppert,1 Bálint Károly Lakatos,1 Márton Tokodi,1 Attila Oláh,1 Szilveszter Braun,1 Christian Karime,1 Zsuzsanna Ladányi,1 Alex Ali Sayour,1 Bálint András Barta,1 Béla Merkely,1 Tamás Radovits,1 Attila Kovács1
1Heart and Vascular Center, Semmelweis University, Városmajor St. 68, Budapest, H-1122, Hungary

Bemutatás módja

Poszter

Szekció

Theoretical and Translational Medicine I. Posters

Language of the presentation

Hungarian

Preferred session

Clinical Medicine

Összefoglaló szövege

Introduction: While global longitudinal strain (GLS) is considered to be a sensitive marker of left ventricular (LV) function, it is influenced by loading conditions.
Aims: We hypothesized that global myocardial work index (GMWI), a novel marker of LV function, may show better correlation with load-independent markers of LV contractility in rat models of pressure-induced or volume overload-induced heart failure.
Methods and results: Male Wistar rats underwent either transverse aortic constriction (TAC; n = 12) or aortocaval fistula creation (ACF; n = 12), inducing LV pressure or volume overload, respectively. Sham procedures were performed to establish control groups (n = 12/12). Echocardiographic loops were obtained to determine GLS and GMWI. Pressure-volume analysis with transient occlusion of the inferior caval vein was carried out to calculate preload recruitable stroke work (PRSW), a load-independent 'gold-standard' parameter of LV contractility. Myocardial samples were collected to assess interstitial and perivascular fibrosis area and also myocardial atrial-type natriuretic peptide (ANP) and brain-type natriuretic peptide (BNP) relative mRNA expression. Compared with controls, GLS was substantially lower in the TAC group (-7.0 ± 2.8 vs. -14.5 ± 2.5%; P < 0.001) and was only mildly reduced in the ACF group (-13.2 ± 2.4 vs. -15.4 ± 2.0%, P < 0.05). In contrast with these findings, PRSW and GMWI were comparable with sham in TAC (110 ± 26 vs. 116 ± 68 mmHg; 1687 ± 275 mmHg% vs. 1537 ± 662 mmHg%; both P = NS), while it was found to be significantly reduced in ACF (58 ± 14 vs. 111 ± 40 mmHg; 1328 ± 411 vs. 1934 ± 308 mmHg%, both P < 0.01). In the pooled population, GMWI (r = 0.70; P < 0.001) but not GLS (r = -0.23; P = 0.12) showed a strong correlation with PRSW. GLS correlated with interstitial (r = 0.61; P < 0.001) and perivascular fibrosis area (r = 0.54; P < 0.001), and also with myocardial ANP (r = 0.85; P < 0.001) and BNP relative mRNA expression (r = 0.75; P < 0.001), while GMWI demonstrated no or only marginal correlation with these parameters.
Conclusions: Being significantly influenced by loading conditions, GLS may not be a reliable marker of LV contractility in heart failure induced by pressure or volume overload. GMWI better reflects contractility in haemodynamic overload states, making it a more robust marker of systolic function.

University and Doctoral School

Semmelweis University, Károly Rácz Doctoral School of Clinical Medicine

Supervisor

I have already earned the PhD degree.

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

1039

Start

10:57

End

11:00

Authors (legacy)

Mihály Ruppert,1 Bálint Károly Lakatos,1 Márton Tokodi,1 Attila Oláh,1 Szilveszter Braun,1 Christian Karime,1 Zsuzsanna Ladányi,1 Alex Ali Sayour,1 Bálint András Barta,1 Béla Merkely,1 Tamás Radovits,1 Attila Kovács1
1Heart and Vascular Center, Semmelweis University, Városmajor St. 68, Budapest, H-1122, Hungary