PhD Scientific Days 2022

Mental Health Sciences III.

Alterations of tryptophan pathway and cytokine profile in migraine patients

Előadó neve

Dr. Gecse, Kinga

Előadó munkahelye

Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University

Előadó telefonszáma

+36202969397

Előadó e-mail címe

gecse.kinga@semmelweis-univ.hu

Az előadás címe

Alterations of tryptophan pathway and cytokine profile in migraine patients

Szerző(k) neve és munkahelye

Kinga Gecse (1,2), Tamás Nagy (1,2,3), György Bagdy (1,4,5), Gabriella Juhász (1,2)
1 Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest
2 SE-NAP2 Genetic Brain Imaging Migraine Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest
3 Department of Measurement and Information Systems, Faculty of Electrical Engineering and Informatics, Budapest University of Technology and Economics, Budapest
4 NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest
5 MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest

Bemutatás módja

Szóbeli

Szekció

Mental Health Sciences III.

Language of the presentation

Hungarian

Preferred session

Mental Sciences

Összefoglaló szövege

Introduction: Tryptophan (TRP) pathway through its metabolites in serotonin and kynurenine (KYN) branches plays a crucial role in migraine pathogenesis. In addition to affecting the release of several neurotransmitters and direct peripheral effects, they also have regulatory influence on inflammatory processes. However, reliable migraine biomarkers have not been identified yet.
Aims: Our aim was to investigate trait-like alterations in tryptophan pathway and cytokine profile in interictal migraine patients without aura compared to healthy controls and their correlation with clinical parameters of migraine.
Methods: Blood samples (BS) were collected to measure plasma TRP, KYN, large neutral amino acids (LNAA), GCSF, MCP-1, RANTES, IL1, IL6, IL8, IL10 and TNFa concentration from 21 females with episodic migraine without aura and 22 healthy control females in two independent time-points. The ratio of TRP to LNAA and KYN to TRP were calculated. Differences of biomarkers between migraine patients and controls were calculated with non-parametric methods in SPSS27. Correlation analyses were also investigated between migraine frequency, age at migraine onset and biological data.
Result: Increased TRP/LNAA (1. BS: U=128, p=0.012; 2. BS: U=143, p=0.033) and decreased RANTES (1.BS: U=329, p=0.017; 2.BS: U=312, p=0.049) concentration were determined in migraine patients compared to controls. In addition, higher frequency of migraine attacks was correlated with lower KYN/TRP ratio (1. BS: rs=-0.451 p=0.046; 2. BS: rs=-0.525 p=0.018) in both time-points.
Conclusion: The increased TRP/LNAA ratio suggest an elevated TRP brain uptake in interictal migraineurs, that might prevent the development of acute attack. However, the correlation between decreased KYN/TRP ratio and increased migraine frequency suggest a downregulated KYN enzyme pathway in migraineurs. Furthermore, the decreased RANTES concentration may be the sign of vascular hypersensitivity in migraine patients.
Funding: Development of scientific workshops of medical, health sciences and pharmaceutical educations (EFOP-3.6.3-VEKOP-16-2017-00009); Hungarian Brain Research Program (2017-1.2.1-NKP-2017-00002, KTIA_13_NAPA-II/14, KTIA_NAP_13-1-2013- 0001, KTIA_NAP_13-2- 2015-0001); 2020-4.1.1.-TKP2020; TKP2021-EGA-25; ERA PerMed (2019-2.1.7-ERA-NET-2020-00005).

University and Doctoral School

Semmelweis University, Doctoral School of Mental Health Sciences

Supervisor

Gabriella Juhász Dr. and György Bagdy Dr.

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

5972

Start

15:15

End

15:30

Authors (legacy)

Kinga Gecse (1,2), Tamás Nagy (1,2,3), György Bagdy (1,4,5), Gabriella Juhász (1,2)
1 Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest
2 SE-NAP2 Genetic Brain Imaging Migraine Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest
3 Department of Measurement and Information Systems, Faculty of Electrical Engineering and Informatics, Budapest University of Technology and Economics, Budapest
4 NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest
5 MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest